九味清瘟饮治疗新型冠状病毒肺炎(奥密克戎)  

COVID-19 (Omicron)Treatment with Jiuwei Qingwen Drink

作　　者：郭敬镕 崔书克[1] 王朝鲁[2] 刘成藏[3] 张天元 李桓[1] 方晓艳[1] 焦河玲[1] 刘锐[3] 曹艳霞[2] 黄建 梁健 陈建立[6] 蔡文 李哲 GUO Jingrong;CUI Shuke;WANG Chaolu;LIU Chengzang;ZHANG Tianyuan;LI Huan;FANG Xiaoyan;JIAO Heling;LIU Rui;CAO Yanxia;HUANG Jian;LIANG Jian;CHEN Jianli;CAI Wen;LI Zhe(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing China 100102;The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450008;Nanyang Traditional Chinese Medicine Hospital,Nanyang Henan China 473007;Zhenping Chinese Medicine Hospital,Zhenping Henan China 474250;Tanghe County Hospital of Traditional Chinese Medicine,Tanghe Henan China 473499)

机构地区：[1]河南中医药大学,河南郑州450046 [2]中国中医科学院望京医院,北京100102 [3]河南中医药大学第三附属医院,河南郑州450008 [4]南阳市中医院,河南南阳473007 [5]镇平县中医院,河南镇平474250 [6]唐河县中医院,河南唐河473499

出　　处：《中医学报》2023年第2期422-426,共5页Acta Chinese Medicine

基　　金：2021年度河南省高等教育教学改革研究与实践(重点课题)项目(2021SJGLX175);河南省特色骨干学科中医学学科建设项目(STG-ZYX03-202130)。

摘　　要：目的:观察九味清瘟饮治疗奥密克戎所致新型冠状病毒肺炎(新冠肺炎)的临床疗效。方法:142例新型冠状病毒肺炎(奥密克戎)患者按照随机数字表法分为观察组与对照组,每组各71例。对照组给予常规治疗,观察组在对照组治疗基础上给予九味清瘟饮治疗。两组疗程均为10 d。比较两组患者临床疗效、中医证候积分、核酸转阴时间、在舱时间及不良反应发生情况。结果:观察组有效率为98.59%,对照组有效率为87.32%,两组有效率比较,差异有统计学意义(P<0.05)。治疗后,两组患者中医证候各分项积分和总积分均显著降低,差异均有统计学意义(P<0.05);观察组发热、咳嗽、咽部不适、神疲乏力、食欲不振及中医证候总积分均显著低于对照组,差异均有统计学意义(P<0.05)。观察组的核酸转阴时间为6(5,8) d,对照组的核酸转阴时间为9(7,10) d,两组核酸转阴时间比较,差异有统计学意义(P<0.05)。观察组在舱时间为8(7,10) d,对照组在舱时间为11(9,12) d,两组在舱时间比较,差异有统计学意义(P<0.05)。观察组1例患者出现恶心;对照组5例患者出现恶心,3例患者出现乏力,1例患者出现轻微腹泻;观察组不良反应发生率为1.41%,对照组不良反应发生率为12.68%,两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:九味清瘟饮联合常规治疗能提高新冠肺炎(奥密克戎)的临床疗效,可显著改善患者的临床症状、中医证候,缩短核酸转阴时间、在舱时间,减少不良反应发生率。Objective:To observe the clinical efficacy of Jiuwei Qingwen Drink in the COVID-19 caused by the Omicron variant.Methods:142 COVID-19 patients(Omicron) were divided into observation group and control group according to the random number table method,with 71 cases in each group.The control group was given conventional treatment,and the observation group was given Jiuwei Qingwen Drink on the basis of the treatment of the control group.The treatment course for both groups was 10 days.The clinical curative effect,TCM syndrome score,nucleic acid negative time,time in the cabin,and occurrence of adverse reactions were compared between the two groups.Results:The effective rate of the observation group was 98.59%,and that of the control group was 87.32%.There was a statistically significant difference between the two groups(P<0.05).After treatment,the sub-items and total scores of TCM syndromes in the two groups were significantly reduced,and the differences were statistically significant(P<0.05).The total scores of fever,cough,pharynx discomfort,mental fatigue,loss of appetite,and TCM syndromes in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The nucleic acid negative time of the observation group was 6(5,8) days,and that of the control group was 9(7,10) days.There was a statistically significant difference between the two groups(P<0.05).The time in the cabin of the observation group was 8(7,10) days,and that of the control group was 11(9,12) days.There was a statistically significant difference between the two groups(P<0.05).In the observation group,nausea occurred in 1 patient.However,in the control group,nausea occurred in 5 patients,fatigue occurred in 3 patients,and mild diarrhea occurred in 1 patient.The incidence of adverse reactions in the observation group was 1.41%,and that in the control group was 12.68%.There was a statistically significant difference between the two groups(P<0.05).Conclusion:Jiuwei Qingwen Drink comb

关 键 词：新型冠状病毒肺炎 九味清瘟饮 奥密克戎 中医证候 

分 类 号：R254.2[医药卫生—中医内科学]