双嘧达莫辅助治疗川崎病患儿的效果及对凝血功能、并发症发生情况的影响  

Effect of dipyridamole in the adjuvant treatment of Kawasaki disease in children and its influences on coagulation function and occurrence of complications

作　　者：吕朝治 LYU Chaozhi(Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院,陕西汉中723000

出　　处：《临床医学研究与实践》2023年第5期82-85,共4页Clinical Research and Practice

摘　　要：目的探究双嘧达莫辅助治疗川崎病(KD)患儿的效果及对凝血功能、并发症发生情况的影响。方法选取2019年1月至2021年5月82例KD患儿作为研究对象,将其随机分为对照组和研究组,各41例。对照组接受人血免疫球蛋白与阿司匹林治疗,研究组在对照组的基础上联合双嘧达莫治疗。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗2周后,研究组的白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。治疗2周后,研究组的D-二聚体、纤维蛋白原(FIB)水平低于对照组,凝血酶时间(TT)长于对照组(P<0.05)。治疗2周后,研究组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原8阳性(CD8^(+))、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平高于对照组,白细胞分化抗原4阳性(CD4^(+))、免疫球蛋白M(IgM)水平低于对照组(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论双嘧达莫联合人血免疫球蛋白、阿司匹林治疗KD患儿的效果显著,可调节凝血功能平衡,改善炎症反应、免疫功能,且不增加并发症发生率,更有利于机体恢复。Objective To explore the effect of dipyridamole in the adjuvant treatment of Kawasaki disease(KD)in children and its influences on coagulation function and occurrence of complications.Methods A total of 82 children with KD from January 2019 to May 2021 were selected as the research objects and randomly divided into control group and study group,with 41 cases in each group.The control group was treated with human blood immunoglobulin and aspirin,and the study group was treated with dipyridamole on the basis of control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment of the study group was higher than that of the control group(P<0.05).After 2 weeks of treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group(P<0.05).After 2 weeks of treatment,the levels of D-dimer and fibrinogen(FIB)in the study group were lower than those in the control group,and the thrombin time(TT)was longer than that in the control group(P<0.05).After 2 weeks of treatment,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 8 positive(CD8^(+)),immunoglobulin A(IgA)and immunoglobulin G(IgG)levels in the study group were higher than those in the control group,and the cluster of differentiation 4 positive(CD4^(+))and immunoglobulin M(IgM)level in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Dipyridamole combined with human blood immunoglobulin and aspirin in the treatment of KD children has a significant effect,it can regulate the balance of coagulation function,improve inflammatory response and immune function,and does not increase the incidence of complications,which is more conducive to body recovery.

关 键 词：川崎病 儿童 双嘧达莫 人血免疫球蛋白 阿司匹林 

分 类 号：R725[医药卫生—儿科]