2019年上海市金山区企业人群的麻疹抗体水平及易感性分析  

Analysis of measles antibody level and susceptibility of enterprise employees in Jinshan District,Shanghai in 2019

作　　者：周杰[1] 马小敏 王芳 李淑华[1] ZHOU Jie;MA Xiao-min;WANG Fang;LI Shu-hua(Jinshan District Center for Disease Control and Prevention,Jinshan 201599,Shanghai,China)

机构地区：[1]上海市金山区疾病预防控制中心,上海金山201599 [2]上海市金山区漕泾镇社区卫生服务中心,上海金山201507

出　　处：《中国生物制品学杂志》2023年第1期65-69,共5页Chinese Journal of Biologicals

基　　金：上海市自然科学基金立项课题(17ZR1424500);上海市卫生计生委立项课题(201740074)。

摘　　要：目的分析2019年上海市金山区企业人群的麻疹抗体水平及易感性,为企业人群麻疹防控工作提供依据。方法采用分层随机抽样方法抽选金山区6家企业共1796名职工,采集静脉血,分离血清,ELISA法检测血清麻疹IgG抗体水平,计算麻疹IgG抗体几何平均浓度(geometric mean concentration,GMC)、抗体阳性率和抗体保护率;应用非条件多因素Logistic回归模型分析影响企业人群的麻疹易感因素。结果1796名监测对象的麻疹抗体GMC为639.71 mIU/mL,阳性率为87.58%,保护率为29.06%。多因素Logistic回归分析显示,与外来户籍人群比较,本市户籍人群易感麻疹的比值比(odds ratio,OR)为1.55(95%CI:1.14~2.12),与≥50岁组人群比较,40~49岁组人群易感麻疹的OR为2.35(95%CI:1.35~4.08)。结论2019年上海金山区企业人群麻疹抗体水平较低,40~49岁组人群特别是本地户籍人群易感麻疹的风险较高,应针对企业高风险人群开展含麻疹成分疫苗补充免疫工作,降低麻疹感染风险和控制麻疹流行。Objective To analyse the level of measles antibody and serological susceptibility of the enterprise employees in Jinshan District,Shanghai in 2019,to provide references for measles prevention and control of enterprise employees.Methods A total of 1796 employees were selected from 6 enterprises in Jinshan District by using a stratified random sampling method,of which serum samples from intravenous blood were collected and determined for IgG antibody level of measles by ELISA.Geometric mean concentration(GMC)of measles IgG antibody,antibody positive rate and antibody protection rate were calculated and the susceptibility factors of measles in enterprise employees were analyzed by using the unconditional multivariate Logistic regression model.Results The GMC of measles antibody in 1796 monitoring objects was 639.71 mIU/mL,the positive rate was 87.58%and the protection rate was 29.06%.Multivariate Logistic regression analysis showed that the odds ratio(OR)of measles susceptibility was 1.55(95%CI:1.14~2.12)in native subjects compared with non-resident subjects,while 2.35(95%CI:1.35~4.08)in subjects aged 40~49 years compared with those aged≥50 years.Conclusion In 2019,the measles antibody level of enterprise employees in Jinshan District of Shanghai was low,and people aged 40~49,especially the native adults,were at high risk of susceptibility to measles.Supplementary immunization with measles vaccine should be carried out for high-risk enterprise employees to reduce the risk of measles infection and control the epidemic situation of measles.

关 键 词：麻疹 抗体 易感性 企业人群 

分 类 号：R181.3[医药卫生—流行病学]