白喉流行及免疫现状  

Status of epidemic and immunization of diphtheria

作　　者：蔡梦瑶 刘宏博(综述) 杨晓明(审校) CAI Meng-yao;LIU Hong-bo;YANG Xiao-ming(Wuhan Institute of Biological Products Co.,Ltd.,Wuhan 430207,Hubei Province,China)

机构地区：[1]武汉生物制品研究所有限责任公司,湖北武汉430207 [2]国家联合疫苗工程技术研究中心,湖北武汉430207 [3]中国生物技术股份有限公司,北京100029

出　　处：《中国生物制品学杂志》2023年第1期112-118,共7页Chinese Journal of Biologicals

基　　金：国家“重大新药创制”科技重大专项资助项目(2018ZX09-738003)。

摘　　要：白喉在大规模免疫接种下,其感染率和发病率曾得到有效控制。但近年来国内外白喉病例频现,除常见儿童感染外,中老年人群患者数量也有所增加,表明白喉的预防及控制依旧不容忽视。本文综述了白喉的病原学特征、致病机制,国内外白喉的流行及免疫现状,并就以上问题进行展望。The infection rate and incidence of diphtheria have been controlled effectively under the large-scale immunization projects.However,in recent years,cases of diphtheria have occurred frequently at home and abroad.Except for common infection in children,the number of middle-aged and elderly patients also increased,indicating that the prevention and control of diphtheria still should not be ignored.This paper reviewed the etiological characteristics,pathogenic mechanism as well as the epidemic and immunization status at home and abroad of diphtheria and looked forward to the above problems.

关 键 词：白喉 流行病学 预防效果 

分 类 号：R186.3[医药卫生—流行病学]