Aminopyrife衍生物的合成及生物活性研究  

Synthesis and biological activity of Aminopyrife derivatives

作　　者：向学慧 李杰 张静[1,2] 高一星 张立新[1,2] XIANG Xue-hui;LI Jie;ZHANG Jing;GAO Yi-xing;ZHANG Li-xin(Institute of Functional Molecules,Shenyang University of Chemical Technology,Shenyang 110142,China;Guangxi Siyue Biotechnology Co.,Ltd.,Nanning 530000,China)

机构地区：[1]沈阳化工大学功能分子研究所,辽宁沈阳110142 [2]广西思钺生物科技有限责任公司,广西南宁530000

出　　处：《化学工程师》2022年第12期9-13,37,共6页Chemical Engineer

基　　金：南宁市科学研究与技术开发计划项目(20201043);南宁市创新创业领军人才“邕江计划”创业项目(2020002-1)。

摘　　要：以Aminopyrife为先导化合物,设计合成了6个氨基吡啶酯类衍生物,并确定其结构。室内生物活性测试结果表明,D-2和D-3具有较好的杀菌活性,质量浓度为100mg·L^(-1)时,对黄瓜霜霉病的防治效果可达到90%以上,质量浓度为25mg·L^(-1)时,对小麦白粉病的防治效果可达到100%,为后续研究提供一定的参考意见。Using Aminopyrife as the lead compound,six aminopyridine ester derivatives were designed and synthesized,and their structures were determined.Laboratory bioactivity test results showed that D-2 and D-3 had good bactericidal activity,and the control effect of 100mg·L^(-1)on cucumber downy mildew could reach 90%,and 25mg·L^(-1)on wheat powdery mildew could reach 100%,which provided certain reference for the follow-up study.

关 键 词：氨基吡啶酯类 杀菌剂 合成 

分 类 号：TQ455[化学工程—农药化工]