Versatile graphitic nanozymes for magneto actuated cascade reaction-enhanced treatment of S.mutans biofilms  

作　　者：Qian Dong Zhaoqian Li Jieqiong Xu Quan Yuan Long Chen Zhuo Chen 

机构地区：[1]Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,College of Biology,Aptamer Engineering Center of Hunan Province,Hunan University,Changsha 410082,China [2]Faculty of Science and Technology,University of Macao,Taipa,Macao 999078,China

出　　处：《Nano Research》2022年第11期9800-9808,共9页纳米研究（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2020YFA0210800);the Science and Technology Innovation Program of Hunan Province(No.2020RC4017);the Science and Technology Development Fund,Macao(No.196/2017/A3).

摘　　要：Pathogenic oral biofilms especially acid-producing ones cause a variety of oral diseases such as dental caries.Given that bacteria are embedded within the biofilms matrix to prevent the penetration of therapeutic drugs,people have explored the applications of nanoparticles to treat oral diseases.However,current nanoparticle-mediated eradication has not achieved the precise treatment of biofilms,and the stabilities of nanoparticles go on strike because of acidic environment leading to poor therapeutic effectiveness.Herein,we design an integrated nanozyme,CoPt@graphene@glucose oxidase(CoPt@G@GOx),which has cascade reaction activity with two-step process.Hydrogen peroxide(H_(2)O_(2))produced through the glucose oxidation by GOx serves as the substrate for peroxidase-mimic CoPt@G to produce highly toxic hydroxyl radical under acidic environment.Compared to the simple mixture of GOx and CoPt@G,CoPt@G@GOx shows around fourfold catalytic effect enhancement.Meanwhile,CoPt@G@GOx can precisely target the location of the biofilms,which ensures the minimal impact on normal softtissues.Relying on the advantage of the magneto-actuated cascade catalytic activity,CoPt@G@GOx reveals a superior antibacterial ability in the Streptococcus mutans biofilms model.Thus,our results provide an easy and effective method to exploit bifunctional nanozyme as a novel topical agent to prevent the prevalent biofilm-induced oral disease.

关 键 词：nanozyme BIOFILM magnetic targeting PLATINUM antibacterial effect 

分 类 号：O64[理学—物理化学]