肠源性尿毒症毒素氧化三甲胺在慢性肾脏病中的研究进展  

Research Progress of Enterogenic Uremic Toxin Trimethylamine Oxide in Chronic Kidney Disease

作　　者：鲁碧玉 胡大军[1] 董佩[1] 邓望月 LU Biyu;HU Dajun;DONG Pei;DENG Wangyue(The Second People's Hospital of Yichang City·Cancer Hospital,Yichang 443000,China;不详)

机构地区：[1]宜昌市第二人民医院·肿瘤医院(三峡大学附属第二人民医院、宜昌市中西医结合医院),湖北宜昌443000

出　　处：《中外医学研究》2023年第2期167-171,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：湖北省教育厅中青年人才项目(Q20211206)。

摘　　要：慢性肾脏病存在特殊的肠道菌群代谢模式,氧化三甲胺是肠道微生物群衍生的三甲胺通过肝脏黄素单加氧酶氧化而产生的一种肠源性尿毒症毒素,可促进慢性肾脏病及并发症的进展,多途径调控肠道菌群及代谢产物氧化三甲胺将为慢性肾脏病的防治提供新的方法。本文针对肠源性尿毒症毒素氧化三甲胺的代谢过程,提出通过优化膳食摄入、控制体重、调节肠道菌群、调控氧化三甲胺生成的通路等新型潜在干预策略来降低氧化三甲胺水平,为延缓慢性肾脏病的进展提供新的治疗思路。Chronic kidney disease posses a special metabolic pattern of intestinal flora.Trimethylamine oxide is a enterogenic uremic toxin derived from trimethylamine originated from intestinal microbiota and oxidized by flavin-containing monooxygenase in the liver,promoting the progress of chronic kidney disease and complications.Multi-channel regulation of intestinal flora and its metabolite trimethylamine oxide will provide a new method for the prevention and treatment of chronic kidney disease.Aiming at the metabolic process of enterogenic uremic toxin trimethylamine oxide,this study proposed novel potential intervention strategies to reduce trimethylamine oxide levels by optimizing dietary intake,controlling body weight,regulating intestinal flora,and regulating the trimethylamine oxide pathway,providing a new treatment idea for delaying the progression of chronic kidney disease.

关 键 词：肠源性尿毒症毒素 氧化三甲胺 慢性肾脏病 干预策略 

分 类 号：R692[医药卫生—泌尿科学]