优杆菌属及其代谢产物短链脂肪酸调控2型糖尿病的研究进展  

Research progress of Eubacterium and its metabolite short-chain fatty acids in regulating type 2 diabetes mellitus

作　　者：李炜东 李莉莎 吕美君 胡琼英[1] 熊大迁[1] Li Weidong;Li Lisha;Lyu Meijun;Hu Qiongying;Xiong Daqian(Department of Laboratory,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;College of Medical Technology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院检验科,成都610072 [2]成都中医药大学医学技术学院,成都610075

出　　处：《中华预防医学杂志》2023年第1期120-124,共5页Chinese Journal of Preventive Medicine

基　　金：四川省重点研发项目(2020YFS0375)。

摘　　要：肠道菌群及代谢产物与2型糖尿病(type 2 diabetes mellitus,T2DM)的进展密切相关,优杆菌属是肠道菌群的主要优势菌群之一,其代谢物短链脂肪酸(short-chain fatty acids,SCFAs)在调节肠道代谢平衡中发挥主导作用。已有研究显示SCFAs具有调节T2DM中胰高血糖素样肽-1分泌、改善胰岛β细胞功能及参与胆汁酸代谢、调节炎性因子生成等作用。本文就优杆菌属及其代谢产物SCFAs与T2DM的关系及调控机制进行阐述。Intestinal flora and its metabolites are closely related to the progression of type 2 diabetes mellitus(T2DM).Eubacterium is one of the dominant intestinal flora,and its metabolites short-chain fatty acids(SCFAs)play a leading role in regulating intestinal metabolic balance.It has been reported that SCFAs can regulate the secretion of glucagon-like peptide-1,improve the function of pancreaticβcells,participate in bile acids metabolism and regulate the production of inflammatory factors in T2DM.Based on the above research background,this article mainly reviews the relationship between Eubacterium and its metabolite SCFAs and T2DM and its regulatory mechanism.

关 键 词：肠道菌群 优杆菌属 短链脂肪酸 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]