东北区域自然人群队列设计与实践  

Design and practice of general population cohort study in northeastern China

作　　者：张合华[1,2] 常青 吴琪俊[1] 夏阳 高山砚[1,2] 张旖骁[2,3] 袁媛 姜晶 邱洪斌[6] 李静[7] 卢春明[8] 纪超[1] 徐昕[1] 黄东辉 戴蕙旭[1] 赵之滢[1] 李行[1] 李晓莹 秦晓松 刘彩刚 马晓宇 徐鑫蕊[1] 姚达[1] 喻慧心 赵玉虹 Zhang Hehua;Chang Qing;Wu Qijun;Xia Yang;Gao Shanyan;Zhang Yixiao;Yuan Yuan;Jiang Jing;Qiu Hongbin;Li Jing;Lu Chunming;Ji Chao;Xu Xin;Huang Donghui;Dai Huixu;Zhao Zhiying;Li Xing;Li Xiaoying;Qin Xiaosong;Liu Caigang;Ma Xiaoyu;Xu Xinrui;Yao Da;Yu Huixin;Zhao Yuhong(Clinical Research Center/Department of Clinical Epidemiology,Shengjing Hospital of China Medical University,Shenyang 110022,China;Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease,Benxi 117004,China;Department of Urology Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Medical Oncology,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Department of Clinical Research,the First Affiliated Hospital of Jilin University,Changchun 130021,China;Department of Epidemiology and Health Statistics,School of Public Health,Jiamusi University,Jiamusi 154007,China;Department of Endocrine and Metabolic Diseases,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Liaoning Provincial Center for Disease Control and Prevention,Shenyang 110005,China;Clinical Laboratory,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Oncology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Data Center,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院临床研究中心/临床流行病学教研室,沈阳110022 [2]辽宁省重大慢病精准医学重点实验室,本溪117004 [3]中国医科大学附属盛京医院泌尿外科,沈阳110004 [4]中国医科大学附属第一医院肿瘤内科,沈阳110001 [5]吉林大学附属第一医院临床研究部,长春130021 [6]佳木斯大学公共卫生学院流行病与卫生统计学系,佳木斯154007 [7]中国医科大学附属第一医院内分泌与代谢病科,沈阳110001 [8]宁省疾病预防控制中心,沈阳110005 [9]中国医科大学附属盛京医院检验科,沈阳110004 [10]中国医科大学附属盛京医院肿瘤科,沈阳110004 [11]中国医科大学附属盛京医院数据中心,沈阳110004

出　　处：《中华流行病学杂志》2023年第1期21-27,共7页Chinese Journal of Epidemiology

基　　金：国家重点研发计划“精准医学研究”重点专项“东北区域自然人群队列研究”项目(2017YFC0907400);辽宁省揭榜挂帅项目“代谢性疾病精准防诊治技术”(2021JH1/10400050);辽宁省科技厅重点研发指导计划项目(2019JH8/10300005)。

摘　　要：2016年我国在国家重点研发计划“精准医学研究”重点专项中发布国家百万自然人群队列建设项目,建设七大区域自然人群队列。东北地区作为我国区域划分七大地区之一,气候特征显著、膳食习惯独特且人口老龄化严重,其慢性非传染性疾病负担居全国前列。因此,建立东北区域大型自然人群队列,系统探寻疾病发生和预后相关区域特色暴露因素,为建立东北地区疾病预防新策略、降低国家医疗负担、提升东北地区人口健康水平,具有重要意义。2018年7月,东北区域自然人群队列现场工作启动,现场工作内容主要包括对参与者进行问卷调查、体格检查,以及血、尿、粪便样本的采集和检测,截至目前,队列总计完成各年龄层共115414人的基线数据收集工作。本文简要介绍了东北区域自然人群队列建设概况,为国内相关研究提供参考。In 2016,a national one million general population cohort project was set up in China for the first time in"Precision Medicine Research"Key Project,National Key Research and Development Program of China,which consists of general population cohorts in seven areas in China.As one of the seven major areas in China,northeastern China has unique climate and specific dietary patterns,and population aging is serious in this area.And the burden of chronic and non-communicable diseases ranks tops in China.Therefore,it is of great significance to establish a large general population cohort in northeastern China to explore the area specific exposure factors related to pathogenesis and prognosis of chronic and non-communicable diseases,develop new prevention strategies to reduce the burden of the diseases and improve the population health in northeastern China.In July 2018,the general population cohort study in northeastern China was launched,the study includes questionnaire survey,health examination and blood,urine and stool sample collection and detection in recruited participants.By now,the cohort has covered all age groups,and the baseline data of 115414 persons have been collected.This paper summarizes the design and practice of the general population cohort study in northeastern China to provide reference for related research in China.

关 键 词：东北 自然人群 前瞻性队列研究 

分 类 号：R195[医药卫生—卫生统计学]