子痫前期孕妇血清FGF5、TF水平与妊娠不良结局的关系  

Relationship between serum FGF5,TF levels and adverse pregnancy outcome in pre-eclampsia pregnant women

作　　者：崔张霞 张娜[1] Cui Zhangxia;Zhang Na(Department of Obstetrics,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi Province,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院产科,陕西咸阳712000

出　　处：《疑难病杂志》2023年第2期172-175,181,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：陕西省教育厅专项科研计划项目(19JK0224)。

摘　　要：目的探究子痫前期孕妇血清成纤维细胞生长因子5(FGF5)、组织因子(TF)水平与妊娠不良结局的相关性。方法选取2017年1月—2022年3月在陕西中医药大学第二附属医院产科就诊的子痫前期孕妇72例为观察组,根据患者病情严重程度分为轻度亚组40例和重度亚组32例,并根据子痫前期患者妊娠结局分为不良妊娠结局亚组22例和妊娠结局良好亚组50例。另选择同期医院产科健康的单胎妊娠孕妇78例作为健康对照组。实时定量PCR法检测血清FGF5表达水平,酶联免疫吸附法测定血清TF水平,采用全自动血凝仪检测血浆中活化部分凝血酶原时间(APTT)、纤维蛋白原(Fib)、凝血酶原时间(PT)、血小板(PLT)水平。Pearson法分析子痫前期患者血清FGF5、TF与血浆凝血指标的相关性。Logistic回归分析影响子痫前期孕妇不良妊娠结局的独立危险因素。结果与健康对照组比较,观察组血清FGF5、TF表达水平升高(t/P=19.916/<0.001、14.530/<0.001)。与轻度亚组比较,重度亚组血清FGF5、TF表达水平升高(t/P=5.624/<0.001、6.938/<0.001)。与妊娠结局良好亚组比较,不良妊娠结局亚组APTT、PT、PLT水平降低(t/P=12.202/<0.001、4.294/<0.001、78.325/<0.001),Fib、FGF5、TF表达水平升高(t/P=6.436/<0.001、10.600/<0.001、12.562/<0.001)。Pearson分析显示,子痫前期患者血清FGF5、TF与APTT、PT、PLT呈负相关(FGF5:r=-0.386、-0.416、-0.463;TF:r=-0.394、-0.434、-0.459,P均<0.001),与Fib呈正相关(r=0.447、0.428,P均<0.001)。Logistic回归分析显示,FGF5高、TF高、Fib高、PLT低是子痫前期孕妇不良妊娠结局的独立危险因素[OR(95%CI)=2.432(1.577~3.750)、2.203(1.494~3.248)、1.957(1.169~3.277)、2.018(1.327~3.069),P<0.05]。结论子痫前期孕妇血清FGF5、TF表达水平显著升高,是子痫前期孕妇不良妊娠结局的独立危险因素。Objective To explore the correlation between the levels of serum fibroblast growth factor 5(FGF5),tissue factor(TF)and adverse pregnancy outcome in pre-eclampsia pregnant women.Methods Seventy-two pregnant women with preeclampsia who were examined and delivered in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from January 2017 to March 2022 were selected as the observation group.According to the severity of the patient's condition,they were divided into mild subgroup of 40 cases and severe subgroup of 32 cases.According to the pregnancy outcome of preeclampsia patients,they were divided into poor pregnancy outcome subgroup of 22 cases and good pregnancy outcome subgroup of 50 cases.In addition,78 singleton pregnant women with healthy obstetrics in the same period were selected as the healthy control group.The expression level of serum FGF5 was detected by real-time quantitative PCR,the level of serum TF was determined by enzyme-linked immunosorbent assay,and the level of activated partial prothrombin time(APTT),fibrinogen(FIB),prothrombin time(PT),and platelet(PLT)in plasma were detected by automatic hemagglutination instrument.Pearson method was used to analyze the correlation between serum FGF5,TF and plasma coagulation index in patients with preeclampsia.Logistic regression analysis was used to analyze the independent risk factors affecting the adverse pregnancy outcome of pre-eclampsia pregnant women.Results Compared with the healthy control group,the expression level of serum FGF5 and TF in the observation group increased(t/P=19.916/<0.001,14.530/<0.001).Compared with mild subgroup,the expression level of serum FGF5 and TF in severe subgroup increased(t/P=5.624/<0.001,6.938/<0.001).Compared with the subgroup with good pregnancy outcome,the levels of APTT,PT and PLT in the subgroup with poor pregnancy outcome decreased(t/P=12.202/<0.001,4.294/<0.001,78.325/<0.001),and the expression levels of FIB,FGF5 and TF increased(t/P=6.436/<0.001,10.600/<0.001,12.562/<0.001).Pearson

关 键 词：子痫前期 成纤维细胞生长因子5 组织因子 不良妊娠结局 相关性 

分 类 号：R714.25[医药卫生—妇产科学]