妊娠期亚临床甲状腺功能减退患者血清IL-6、TNF-α、IGF-1水平与血脂、甲状腺功能和妊娠结局的关系  

Relationship between serum IL-6,TNF-α,IGF-1 levels and blood lipids,thyroid function and pregnancy outcome in patients with subclinical hypothyroidism during pregnancy

作　　者：沈娟娟[1] 哈丽亚·哈力木别克[1] 王登兰[1] 蔡珏瑾[1] 木克达思·艾合买提 Shen Juanjuan;Haliya Halimubieke;Wang Denglan;Cai Juejin;Mukedasi Aihemaiti(Department of Obstetrics,Second Affiliated Hospital of Xinjiang Medical University,Xinjiang Province,Urumqi 830063,China)

机构地区：[1]新疆医科大学第二附属医院产科,乌鲁木齐830063

出　　处：《疑难病杂志》2023年第2期176-181,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：新疆维吾尔自治区自然科学基金项目(2019D01C238)。

摘　　要：目的探讨妊娠期亚临床甲状腺功能减退(SCH)患者血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、胰岛素样生长因子-1(IGF-1)表达与血脂、甲状腺功能和妊娠结局的关系。方法选择2018年3月—2020年9月新疆医科大学第二附属医院产科收治妊娠期SCH患者52例作为观察组,并根据妊娠结局分为妊娠正常亚组42例、妊娠不良亚组10例,另选择同期非SCH孕妇35例作为对照组。观察比较各组孕妇血清IL-6、TNF-α、IGF-1水平及血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、空腹血糖(FPG)、肾功能[血尿素氮(BUN)、肌酐(SCr)、尿酸(UA)]和甲状腺功能指标[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)],分析SCH孕妇血清IL-6、TNF-α、IGF-1水平与血脂、甲状腺功能的关系。结果与对照组比较,观察组孕妇血清IL-6、TNF-α、TC、TG、LDL-C、TSH水平均明显升高(t/P=4.697/<0.001、5.815/<0.001、2.311/0.023、2.214/0.030、3.168/0.002、2.245/0.027),而IGF-1水平明显降低(t/P=2.959/0.004);2组HDL-C、FPG、BUN、SCr、UA、FT4、FT3比较差异无统计学意义(P>0.05)。妊娠不良亚组孕妇血清IL-6、TNF-α水平明显高于妊娠正常亚组(t/P=2.706/0.009、2.105/0.040),而IGF-1水平明显低于妊娠正常亚组(t/P=2.335/0.024)。Pearson相关分析结果显示,血清IL-6、TNF-α均与TC、TG、LDL-C、HDL-C、TSH、FT4、FT3水平呈正相关,IGF-1与TSH呈负相关(P均<0.05)。结论妊娠期SCH患者血清IL-6、TNF-α水平升高,IGF-1水平降低,且与血脂、甲状腺功能及妊娠不良结局有关。Objective To investigate the serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in patients with subclinical hypothyroidism(SCH)during pregnancy.The relationship between the expression of insulin-like growth factor-1(IGF-1)and blood lipid,thyroid function and pregnancy outcome.Methods From March 2018 to September 2020,52 patients with SCH were selected as the observation group in the Obstetrics Department of the Second Affiliated Hospital of Xinjiang Medical University,and were divided into 42 normal pregnancy subgroups and 10 poor pregnancy subgroups according to the pregnancy outcome.In addition,35 non-SCH pregnant women in the same period were selected as the control group.Observe and compare the serum IL-6 and TNF-αof pregnant women in each group,IGF-1 level and blood lipid[total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],fasting blood glucose(FPG),renal function[blood urea nitrogen(BUN),creatinine(SCR),uric acid(UA)]and thyroid function indicators[thyroid stimulating hormone(TSH),free triiodothyronine(FT 3),free thyroid hormone(FT 4)].Analysis of serum IL-6 and TNF-αin pregnant women with SCH,the relationship between IGF-1 level and blood lipid,thyroid function.Results Compared with the control group,the serum IL-6 and TNF-αof pregnant women in the observation group,the levels of TC,TG,LDL-C and TSH increased significantly(t/P=4.697/<0.001,5.815/<0.001,2.311/0.023,2.214/0.030,3.168/0.002,2.245/0.027),while the levels of IGF-1 decreased significantly(t/P=2.959/0.004);There was no significant difference in HDL-C,FPG,BUN,SCR,UA,FT 4 and FT 3 between the two groups(P>0.05).Serum IL-6 and TNF-αof pregnant women in poor pregnancy subgroup The level of IGF-1 was significantly higher than that of normal pregnancy subgroup(t/P=2.706/0.009,2.105/0.040),while the level of IGF-1 was significantly lower than that of normal pregnancy subgroup(t/P=2.335/0.024).Pearson correlation analysis showed that serum IL-6 and TNF-αwere pos

关 键 词：亚临床甲状腺功能减退 妊娠期 白介素-6 肿瘤坏死因子-α 胰岛素样生长因子-1 血脂 甲状腺功能 妊娠结局 相关性 

分 类 号：R581.2[医药卫生—内分泌] R714.256[医药卫生—内科学]