颈椎病相关信号通路的研究进展  

Research progress of signal pathway related to cervical spondylosis

作　　者：刘家邑 刘彤 钱鑫[1] 麻东阳 张成 陈丽丽[1] 胡哲 齐伟[1,2] LIU Jia-yi;LIU Tong;QIAN Xin;MA Dong-yang;ZHANG Cheng;CHEN Li-li;HU Zhe;QI Wei(Changchun University of Chinese Medicine,Changchun,Jilin 130017,China;不详)

机构地区：[1]长春中医药大学,吉林长春130017 [2]深圳市宝安纯中医治疗医院,广东深圳518101

出　　处：《中国临床研究》2023年第1期134-138,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金资助项目(82074570);吉林省自然科学基金(20210101193JC)。

摘　　要：颈椎病是由于颈椎间盘的退行性病变,从而使颈椎间盘处软骨细胞出现凋亡、衰老等病理改变,最终出现关节结构改变及广泛性的颈部疼痛。但其发病机制尚未明确,了解与颈椎病相关的通路对深入探究颈椎病的发病机制及探索未知的治疗靶点具有实际意义。本文围绕颈椎病的相关通路的研究进展作一综述,发现NF-κB、JAK/STAT、PI3K/Akt、MAPK、Wnt以及整合素-FAK信号通路与颈椎类相关疾病的产生与发展均有密切联系,且与各信号通路相关的中医内外治法实验研究取得了可喜的效果。期望此文能为颈椎病的发病机制及前沿治疗手段提供一定的科学参考依据。Cervical spondylosis is caused by degenerative lesions of the cervical intervertebral discs,resulting in pathological changes such as apoptosis and senescence of cartilage cells at the cervical intervertebral discs,and ultimately structural changes in the joints and widespread neck pain.However,the pathogenesis of cervical spondylosis is not yet clear,and understanding the pathways associated with cervical spondylosis is of practical importance in exploring the pathogenesis of cervical spondylosis and exploring unknown therapeutic targets.This paper reviews the progress of research on the pathways associated with cervical spondylosis and finds that cervical spondylosis is closely associated with NF-κB,JAK/STAT,PI3K/Akt,MAPK,Wnt and integrin-FAK signalling pathway,and the experimental research of internal and external treatment of traditional Chinese medicine related to various signal pathways has achieved gratifying results.It is hoped that this article will provide some scientific basis for the pathogenesis and cutting-edge treatment of cervical spondylosis.

关 键 词：颈椎病 信号通路 中医疗法 

分 类 号：R681.5[医药卫生—骨科学]