D-氯前列醇钠在奶牛体内的药代动力学研究  

Study on Pharmacokinetics of D-cloprostol Sodium in Dairy Cows

作　　者：李香[1] 李青云 张欣 唐熙 侯佳琪 辛怡霖 李引乾[2] LI Xiang;LI Qing-yun;ZHANG Xin;TANG Xi;HOU Jia-qi;XIN Yi-lin;LI Yin-qian(Shaanxi Animal Disease Prevention and Control Center,Xi’an,Shaanxi,710016,China;College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China)

机构地区：[1]陕西省动物疫病预防控制中心,陕西西安710016 [2]西北农林科技大学动物医学院,陕西杨凌712100

出　　处：《动物医学进展》2023年第1期26-30,共5页Progress In Veterinary Medicine

基　　金：陕西省农业农村厅项目(畜牧专项资金-XN15)。

摘　　要：D-氯前列醇钠为人工合成的前列腺素(PGF2α)类似物。为分析D-氯前列醇钠在奶牛体内的药物代谢动力学过程,为兽医临床合理用药提供理论依据,对6头奶牛进行单剂量肌肉注射D-氯前列醇钠,24 h内不同时间20次静脉采血,应用高效液相色谱法(HPLC)测定血清中D-氯前列醇钠浓度,用3P97软件拟合药时曲线,计算药物动力学参数。结果显示,D-氯前列醇钠在奶牛体内的药物动力学配置符合有吸收因素一室模型,主要药物动力学参数:消除相半衰期t_(1/2kel)、药-时曲线下面积AUC、消除速率常数kel、峰浓度C_(max)和达峰时间T_(max)分别为(4.528±0.803)h、(581.400±216.838)ng·mL^(-1)·h、(0.158±0.029)h^(-1)、(71.172±32.440)ng·mL^(-1)、(1.600±0.164)h。结果表明,奶牛肌肉注射D-氯前列醇钠后,吸收迅速,消除相对较快。D-cloprostenol sodium is a synthetic prostaglandin(PGF2α)analogue.To analyze the pharmacokinetics of d-chloroprostol sodium in dairy cows and provide theoretical basis for veterinary clinical rational drug use,six dairy cows were injected with a single dose of d-chloroprostol sodium intramuscularly,and blood was collected 20 times at different times within 24hours.The concentration of D-cloprostol sodium in serum was determined by high performance liquid chromatography.The pharmacokinetic parameters were calculated by fitting the drug time curve with 3P97 software.The results showed that the pharmacokinetic configuration of d-chloroprostol sodium in dairy cows accorded with the one compartment model with absorption factors.Main pharmacokinetic parameters:t_(1/2kel)=(4.528±0.803)h,AUC=(581.400±216.838)ng·mL^(-1)·h,Kel=(0.158±0.029)h^(-1),C_(max)=(71.172±32.440)ng·mL^(-1),T_(max)=(1.600±0.164)h.The results showed that after intramuscular injection of D-chloroprostol sodium,the cows absorbed rapidly and eliminated relatively quickly.

关 键 词：D-氯前列醇钠 奶牛 药物动力学 高效液相色谱 肌肉注射 

分 类 号：S859.79.3[农业科学—临床兽医学] S858.23[农业科学—兽医学]