合成医用高分子材料的抗凝血改性研究进展  

Research progress on modification of anticoagulant for synthetic medical polymers

作　　者：马慧君 支树迪 袁坤山 张守城 张海军 MA Hui-jun;ZHI Shu-di;YUAN Kun-shan;ZHANG Shou-cheng;ZHANG Hai-jun(National-Local United Engineering Laboratory for Biomedical Material Modification Technology,Dezhou 251100,China;Department of Interventional Vascular,The Institute of Interventional and Vascular,Tongji University,Shanghai 200072,China)

机构地区：[1]生物医用材料改性技术国家地方联合工程实验室肿瘤护理项目组,山东德州251100 [2]同济大学介入血管研究所介入血管科,上海200072

出　　处：《现代化工》2022年第12期75-78,共4页Modern Chemical Industry

摘　　要：主要讨论了合成医用高分子材料表面的抗凝血改性方法进展,介绍了以肝素、类肝素和其他新兴药物为有效成分的表面抗凝药物涂层技术,同时介绍了合成医用高分子材料表面亲水性改性、官能团改性技术的进展,指出了现存的主要问题,并对未来发展进行了展望。This review mainly focuses on the progress in the anticoagulant modification methods on the surface of synthetic medical polymer materials, introduces the surface anticoagulant drug coating technology with heparin, heparinoid and other emerging drugs as active ingredients, introduces the progress in hydrophilic modification and functional group modification technology on the surface of this materials, points out the main existing problems, and prospects the future development.

关 键 词：合成医用高分子材料 医疗器械 抗凝血 血液相容性 表面改性 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]