某儿童医院门诊超说明书用药情况调查分析  

A Survey of Off-Label Drug Use in Outpatient of A Children′s Hospital

作　　者：李天姿 金彦 唐淑含 LI Tian-zi;JIN Yan;TANG Shu-han(Department of Pharmacy,Harbin Children's Hospital,Harbin 150010,China)

机构地区：[1]哈尔滨市儿童医院临床药学部,哈尔滨150010

出　　处：《中国药学杂志》2022年第23期2030-2034,共5页Chinese Pharmaceutical Journal

摘　　要：目的调查某儿童医院超说明书用药情况,为加强儿童用药安全管理提供依据。方法采取回顾性分析的方法,随机抽取该儿童医院2021年1月至12月的门诊处方进行点评,根据药品说明书对处方的超说明书用药行为进行判断及归类。结果共调查有效处方2514张,含医嘱7159条,涉及264种药品,超说明书用药发生率按处方数为57.24%,按医嘱条数为27.34%。主要超说明书的类型为未提及儿童用药信息(57.23%)和超适应证或功能主治(25.86%)。结论该院门诊超说明书用药现象普遍,多种药物缺乏关于儿童使用的信息。建议医院结合国家最新法律政策,完善超说明书用药管理制度,细化儿科超说明书用药规范,确保儿童用药安全。OBJECTIVE To investigate the off-label drug use in hospitals and provide data for strengthening the safety management of children′s medication.METHODS By retrospective analysis,the outpatient prescriptions of the children′s hospital from January to December in 2021 were randomly selected for comments,and the off-label drug use behaviors of prescriptions were judged and classified according to the drug instructions.RESULTS A total of 2514 effective prescriptions,including 7159 medical orders,involving 264 drugs were investigated.The incidence of off-label drug use was 57.24%according to prescription and 27.34%according to medical orders.The main types of off-label were no information on medication for children(57.23%)and off-label or functional indications(25.86%).CONCLUSION Off-label drug use is commonly seem in the outpatient department of the hospital,with a lack of information about the use of various drugs in children.It is suggested that the hospital should improve the management system of off-label drug use in accordance with the latest national laws and policies,and specify the specifications of off-label drug use in pediatrics,so as to ensure the safety of drug use in children.

关 键 词：超说明书用药 儿科 门诊处方 合理用药 用药安全 

分 类 号：R969.3[医药卫生—药理学]