中国大陆首例猴痘确诊病例流行病学调查和处置  

Epidemiological investigation and management of the first confirmed human monkeypox case in Chinese mainland

作　　者：李婷婷 李柏松[1] 唐文革[1] 曾德唯[2] 黄中[3] 李周蓉 杨钰隆 黄为[1] 凌华[1] 李勤[1] 漆莉[1] Li Tingting;Li Baisong;Tang Wenge;Zeng Dewei;Huang Zhong;Li Zhourong;Yang Yulong;Huang Wei;Ling Hua;Li Qin;Qi Li(Chongqing Center for Disease Prevention and Control,Chongqing 400042,China;Nan’an District Center for Disease Prevention and Control of Chongqing City,Chongqing 400067,China;Yubei District Center for Disease Prevention and Control of Chongqing City,Chongqing 401120,China;School of Public Health,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆市疾病预防控制中心,400042 [2]重庆市南岸区疾病预防控制中心,400067 [3]重庆市渝北区疾病预防控制中心,401120 [4]重庆医科大学公共卫生学院,400016

出　　处：《国际病毒学杂志》2022年第5期391-394,共4页International Journal of Virology

基　　金：重庆市科技局技术创新与应用发展重点项目(CSTC2021jscx-gksb-N0005)。

摘　　要：目的描述中国大陆首例猴痘确诊病例的发病过程、流行病学特征和疫情处置过程,为今后猴痘疫情防控提供参考依据。方法对病例开展现场流行病学调查。采集病例的口咽拭子、鼻咽拭子和疱疹液标本,应用实时荧光定量多聚核苷酸链式反应方法对标本进行猴痘病毒核酸检测。结果病例于当地时间9月3日在欧洲某国发生一次高风险暴露行为,9月9日出现喉咙干痒,11日发现皮疹。9月14日回国后,主动向隔离点医生报告相关症状,其口咽拭子、鼻咽拭子和疱疹液样本经国家疾病预防控制中心复核均为猴痘病毒阳性,16日确诊为猴痘病例。基因测序结果显示,病例感染的猴痘病毒属西非系B.1分支。结论综合流行病学调查和实验室结果,该猴痘确诊病例系境外输入感染引起。猴痘逐渐成为威胁人类健康的全球公共卫生问题,中国应做好猴痘疫情监测和防控工作。Objective To describe the disease onset,epidemiological characteristics and epidemic management process of the first human monkeypox case in the Chinese mainland,so as to provide a reference for further prevention and control of monkeypox.Methods Field epidemiological investigations were conducted for the patient.The oropharyngeal swabs,nasopharyngeal swabs and herpes fluid specimens from the patient were collected,and the fluorescent quantitative real-time polymerase chain reaction(PCR)was used to detect the monkeypox virus nucleic acid in the specimens.Results The patient had a high-risk exposure in an European country on September 3.On September 9,dry throat itching appeared and on September 11,rashes were observed.After returning to China on September 14,the patient reported actively the symptoms to the doctor in the quarantine hotel.Oropharyngeal swabs,nasopharyngeal swabs,and herpes fluid specimens were confirmed positive for the monkeypox virus by Chinese Center for Disease Control and Prevention.On September 16,the patient was diagnosed as human monkeypox case.The sequencing results indicated that the infected monkeypox virus belonged to the B.1 branch of the West African lineage.Conclusions Combined with the results of epidemiological investigations and laboratory,the monkeypox case was confirmed as an imported case from aboard.Monkeypox is becoming a global public health concern that threats human health.The surveillance of monkeypox in China should be enhanced.

关 键 词：猴痘 中国大陆 首例 输入感染 

分 类 号：R511[医药卫生—内科学] R181.3[医药卫生—临床医学]