植物源天然产物协同抗生素抗MRSA的研究进展  

Research progress of synergistic anti-MRSA effects of plant-derived natural products combined with antibiotics

作　　者：王宗朝 张洁[1] 丁超月 郭银辉 潘源虎[1] Wang Zong-chao;Zhang Jie;Ding Chao-yue;Guo Yin-hui;Pan Yuan-hu(National Reference Laboratory of Veterinary Drug Residues(HZAU)and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods,College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070)

机构地区：[1]华中农业大学国家兽药残留基准实验室(HZAU)、农业部食品兽药残留检测重点实验室,动物科学技术学院动物医学院,武汉430070

出　　处：《中国抗生素杂志》2022年第11期1128-1138,共11页Chinese Journal of Antibiotics

基　　金：十三五国家重点研发计划(No.2017YFD0501400)。

摘　　要：耐甲氧西林金黄色葡萄球菌(MRSA)在世界各地感染率和分离率不断升高,常用抗菌药物的治疗作用逐渐减弱甚至无效,因此迫切需要一种新的治疗MRSA感染的手段。植物源天然产物因其新颖复杂的化学结构表现出广泛的生物活性,作为增效剂协同抗生素对抗MRSA的作用已有大量报道。本文主要综述了自2016年来的植物源天然产物协同抗生素对抗MRSA的作用及机制,以期为进一步的研究提供参考。The infection and isolation rates of methicillin-resistant Staphylococcus aureus(MRSA)are increasing all over the world,and the therapeutic effects of commonly used antibiotic have gradually weakened or even become ineffective.Therefore,new approaches for the treatment of MRSA infection are urgently needed.Plant-derived natural products exhibit a wide range of biological activities due to their novel and complex chemical structures,and their effects as antibiotic adjuvants against MRSA have been reported in large numbers.This article mainly reviews the effects and mechanisms of plant-derived products combined with antibiotics against MRSA since 2016,hoping to provide a reference for further research.

关 键 词：天然产物 耐甲氧西林金黄色葡萄球菌 抗生素 协同作用 机制 

分 类 号：R978.1[医药卫生—药品]