血清肝细胞生长因子评估儿童肺炎支原体肺炎的临床价值  

Clinical Value of Serum Hepatocyte Growth Factor in the Evaluation of Mycoplasma Pneumoniae Pneumonia in Children

作　　者：李超 LI Chao(Department of Pediatrics,Maoming People's Hospital,Maoming Guangdong 525000,China)

机构地区：[1]茂名市人民医院儿科,广东茂名525000

出　　处：《中国卫生标准管理》2023年第1期38-42,共5页China Health Standard Management

摘　　要：目的探讨在儿童肺炎支原体肺炎评估中实施血清肝细胞生长因子水平检测的临床价值。方法2019年1月—2021年6月从茂名市人民医院择取60例肺炎支原体肺炎患儿作为研究组,根据病情严重程度可以分为两组,20例重症支原体肺炎患儿纳入研究一组,40例非重症支原体肺炎患儿纳入研究二组,另外择取20例健康体检儿童作为对照组,通过酶联免疫吸附法对血清肝细胞生长因子水平进行检测,并通过全自动生化分析仪测定研究组患儿的血清C-反应蛋白浓度、乳酸脱氢酶浓度,对照分析上述几组的检验结果。结果研究组血清肝细胞生长因子水平均高于对照组,差异有统计学意义(P<0.05);从临床特征与实验室特点分析,研究一组年龄大于研究二组,住院时间比研究二组长,支气管肺炎类型的胸片患者多于研究二组,差异有统计学意义(P<0.05);研究一组的血清肝细胞生长因子、血清C-反应蛋白浓度、乳酸脱氢酶浓度明显高于研究二组,差异有统计学意义(P<0.05)。结论在儿童肺炎支原体肺炎评估中,血清肝细胞生长因子水平检测具备显著临床价值,可以评估病情严重程度,还可以为临床治疗效果评估提供指导作用。Objective To explore the clinical value of serum hepatocyte growth factor in the evaluation of mycoplasma pneumoniae pneumonia in children.Methods From January 2019 to June 2021,a total of 60 children with mycoplasma pneumoniae pneumonia from Maoming People's Hospital were selected as the study group,which can be divided into two groups according to the severity of the disease.20 chi ldren with severe mycoplasma pneumoniae were included in the first group,40 children with non severe mycoplasma pneumoniae were included in the second group,and 20 healthy children were selected as the control group.The level of serum hepatocyte growth factor was detected by enzyme-linked immunosorbent assay,and the concentration of serum C-reactive protein and lactate dehydrogenase in the s tudy g roup were measured by automatic biochemical analyzer.The test results of the above groups were compared and analyzed.Results The level of serum hepatocyte growth factor in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).From the analysis of clinical characteristics and laboratory characteristics,the age of study group 1 was older than study group 2,the length of hospital stay was longer than study group 2,and the patients with bronchopneumonia type on chest X-ray were more than study group 2,and the difference was statistically significant(P<0.05).Serum hepatocyte growth factor,serum C-reactive protein concentration and lactate dehydrogenase concentration in study group 1 were significantly higher than those in study group 2,and the difference was statistically significant(P<0.05).Conclusion The detection of serum hepatocyte growth factor level has significant clinical value in the evaluation of mycoplasma pneumoniae pneumonia in children.It can not only evaluate the severity of the disease,but also provide guidance for the evaluation of clinical treatment effect.

关 键 词：血清肝细胞生长因子水平 儿童肺炎支原体肺炎 血清C-反应蛋白浓度 乳酸脱氢酶浓度 病情严重程度 病情评估 

分 类 号：R725[医药卫生—儿科]