呋塞米介入对^(18)F-脱氧葡萄糖正电子发射计算机断层显像的放射防护作用  

Radiation protection effect of furosemide intervention on ^(18)F-FDG PET/CT imaging

作　　者：倪茵 胡晓燕[1] 胡岚萍 罗娜娜 邱大胜[1] Ni Yin;Hu Xiaoyan;Hu Lanping;Luo Nana;Qiu Dasheng(Departmen of Nuclear Medicine,Hubei Tumor Hospital,Wuhan 430079,China)

机构地区：[1]湖北省肿瘤医院核医学科,武汉430079

出　　处：《中华放射医学与防护杂志》2022年第12期980-983,共4页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的探讨呋塞米介入^(18)F-脱氧葡萄糖(^(18)F-FDG)正电子发射计算机断层显像(PET/CT)的放射防护作用。方法 146例患者按随机数表法随机分为两组, 实验组74例, 对照组72例。试验组注射前口服呋塞米40 mg, 正常对照组未行特殊处理, ^(18)F-FDG注射60、120 min后, 分别在其正面前胸、腹水平测量0.5 m处周围剂量当量率。结果试验组注射^(18)F-FDG后60 min胸部及腹部、120 min胸部及腹部的周围剂量当量率分别为(30.80±8.61)、(41.38±11.06)、(18.26±4.85)和(24.66±6.50)μSv/h, 均低于对照组, 差异有统计学意义(t=15.36、13.13、18.73、17.29, P<0.05)。试验组和对照组的纵隔SUV_(max)、肝脏SUV_(max)差异无统计学意义(P>0.05)。多因素分析显示, 是否服用速尿、体表面积是影响周围剂量当量率的主要影响因素(t=-13.52、2.96, P<0.05), 年龄、性别对周围剂量当量率的影响不明显(P>0.05)。结论呋塞米介入可促进排尿, 在不影响影像质量的前提下有效降低了受检者的体内辐射, 有较好的放射防护作用。Objective To investigate the radiation protection effect of furosemide intervention on ^(18)F-2-deoxy-D-glucose(^(18)F-FDG)positron emission tomography/computed tomography(PET/CT)imaging.Methods A total of 146 patients were randomly divided into two groups,with test group of 74 patients and control group of 72.The test group was administrated orally with furosemide of 40 mg for each one before injection,while the normal control group did not undergo special treatment.60 and 120 min after ^(18)F-FDG injection,the horizontal measurement of ambient dose equivalent rates was carried out at 0.5 m from the front of both chest and abdomen respectively.Results For the test group,the ambient dose equivalent rates were measured to be(30.80±8.61)and(41.38±11.06)μSv/h 60 min after injection of ^(18)F-FDG whereas(18.26±4.85)and(24.66±6.50)μSv/h 120 min after injection,respectively,both lower than in the control group and with statistically significant difference between the both(t=15.36,13.13,18.73,17.29,P<0.05).No significant difference was found between mediastinal SUV_(max) and liver SUV_(max) in the experimental group and control group(P>0.05).Multivariate ANOVA showed that body surface area was a major factor influencing ambient dose equivalent rate regardless of furosemide injection(t=-13.52,2.96,P<0.05),and no obvious effects of age and sex on ambient dose equivalence rate were found.Conclusions Furosemide intervention can promote urination,effectively reduce the internal radiation exposure of the examinated patietns in the premise of not affecting the image quality,and therefore provide a better radiation protection effect.

关 键 词：18氟-脱氧葡萄糖 正电子发射计算机断层显像 呋塞米 周围剂量当量率 

分 类 号：R817.4[医药卫生—影像医学与核医学]