羟基磷灰石/Ti-13Nb-13Zr复合材料的组织性能与细胞相容性评价  

Microstructure,properties and cytocompatibility evaluation of hydroxyapatite/Ti-13Nb-13Zr composites

作　　者：王唯 孟增东[2] 罗丽琳[2] 张玉勤[1,3] 蒋业华 WANG Wei;MENG Zengdong;LUO Lilin;ZHANG Yuqin;JIANG Yehua(School of Materials Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China;Department of Orthopedics,First People's Hospital of Yunnan Province,Kunming 650032,China;Engineering Technology Research Center of Titanium Products and Application of Yunnan Province,Chuxiong 650032,China)

机构地区：[1]昆明理工大学材料科学与工程学院,昆明650093 [2]云南省第一人民医院骨科,昆明650032 [3]云南省钛材应用产品工程技术研究中心,楚雄651209

出　　处：《复合材料学报》2023年第1期428-436,共9页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金项目(31660262)。

摘　　要：为了改善Ti-13Nb-13Zr医用钛合金的生物活性与细胞相容性,利用放电等离子烧结(SPS)技术制备了Ti-13Nb-13Zr合金和羟基磷灰石(HA)含量5wt%的5HA/Ti-13Nb-13Zr复合材料并进行退火处理,研究了两种材料的显微组织、力学性能、表面润湿性、体外矿化行为及细胞增殖与凋亡等生物学性能。结果表明:合金主要由β-Ti和α-Ti相组成,复合材料由β-Ti、α-Ti、HA相及少量陶瓷反应相(Ca_(3)(PO_(4))_(2)、CaZrO_(3)、CaO)组成,退火后部分初生α-Ti转变为β-Ti且组织更均匀,HA的加入会使得晶粒细化;退火后两种材料抗压强度、屈服强度、屈强比和弹性模量均略微下降;HA的加入提高了复合材料亲水性、类骨磷灰石形成能力、细胞增殖率并降低了细胞凋亡率;综合分析,退火后的5HA/Ti-13Nb-13Zr复合材料抗压强度、屈服强度和弹性模量分别为(1744±9)MPa、(1493±12)MPa和(43±1.6)GPa,具有优异的类骨磷灰石形成能力,同时细胞增殖率达到99.1%±0.8%,表明HA的加入明显提高了Ti-13Nb-13Zr合金的生物活性与细胞相容性。In order to improve the bioactivity and cytocompatibility of Ti-13Nb-13Zr biomedical titanium alloy,Ti-13Nb-13Zr alloy and 5HA/Ti-13Nb-13Zr composite with hydroxyapatite(HA)content 5wt%were fabricated by spark plasma sintering(SPS)technique and then annealed.The microstructure,mechanical properties,surface wettability,in vitro mineralization behavior,cell proliferation and apoptosis of the two materials were investigated.The results show that the alloy is mainly composed ofβ-Ti andα-Ti phases,and the composite is mainly composed ofβ-Ti,α-Ti,HA phases and a small amount of ceramic reaction phases(Ca_(3)(PO_(4))_(2),CaZrO_(3),CaO).After annealing,the part ofα-Ti transforms toβ-Ti and the microstructure is more uniform.The addition of HA can refine the grains to a certain extent.The compressive strength,yield strength,yield ratio and elastic modulus of the two materials decrease slightly after annealing.The HA not only strengthens the hydrophilicity and osteoapatite-like formation ability,but also increases cell viability rate and cell apoptosis rate of the composites.Comprehensive analysis,the compressive strength,yield strength and elastic modulus of the 5HA/Ti-13Nb-13Zr are(1744±9)MPa,(1493±12)MPa and(43±1.6)GPa,respectively.Moreover,the 5HA/Ti-13Nb-13Zr composite have excellent bone-like apatite formation ability and the cell viability reaches 99.1%±0.8%.It indicated that the addition of HA significantly improves the bioactivity and cytocompatibility of Ti-13Nb-13Zr alloy.

关 键 词：钛基复合材料 退火处理 显微组织 力学性能 细胞相容性 

分 类 号：TB332[一般工业技术—材料科学与工程]