静脉双膦酸盐相关急性相反应的研究进展  

Research progress of acute phase reaction related to intravenous bisphosphonates

作　　者：田欣 传丰宁 周波[1] Tian Xin;Chuan Fengning;Zhou Bo(Department of Endocrinology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China)

机构地区：[1]重庆医科大学附属第一医院内分泌内科,400042

出　　处：《国际内分泌代谢杂志》2022年第6期489-492,共4页International Journal of Endocrinology and Metabolism

摘　　要：双膦酸盐作为一种在骨代谢疾病方面十分重要的药物,目前在国际上主要应用于骨质疏松症、高钙血症、Paget骨病、成骨不全和肿瘤骨转移的防控等,其具有使用方便、效果好、耐受性佳等特点,但使用双膦酸盐时仍偶有不良反应发生。既往研究表明,急性相反应(acute phase reaction,APR)是静脉使用双膦酸盐最常见的不良反应,不仅降低患者的生活质量,而且对长期持续治疗的依从性和疗效产生负面影响。本文主要就静脉使用双膦酸盐相关性APR的研究进展进行讨论,以提高医务人员对APR特征的认识。Bisphosphonates as a very important drug in bone metabolic diseases.At present,bisphosphonates are mainly used in the prevention and treatment of osteoporosis,hypercalcemia,Paget′s bone disease,osteogenesis imperfecta and tumor bone metastasis,etc.It has the characteristics of convenient,effective,and tolerable,but there are still occasional adverse reactions when using bisphosphonates.Previous studies have shown that acute phase reaction(APR)is the most common adverse reaction of intravenous bisphosphonate,which not only reduces the quality of life of patients,but also has a negative impact on the compliance and efficacy of long-term continuous treatment.This article mainly aims to discussing the research progress of intravenous bisphosphonate-related APR in order to improve medical staff′s awareness of APR.

关 键 词：双膦酸盐 急性相反应 不良反应 

分 类 号：R969.3[医药卫生—药理学]