糖尿病肾脏病治疗的新靶点--补体系统  

The complement system as a new target for the treatment of diabetic kidney disease

作　　者：刘向阳 许朝飞 孙蓓[1] 陈莉明[1] Liu Xiangyang;Xu Chaofei;Sun Bei;Chen Liming(NHC Key Laboratory of Hormones and Development,Tianjin Key Laboratory of Metabolic Diseases,Chu Hsien-ⅠMemorial Hospital&,Tianjin Institute of Endocrinology,Tianjin Medical University,Tianjin 300134,China)

机构地区：[1]天津医科大学朱宪彝纪念医院,天津市内分泌研究所,国家卫生健康委员会激素与发育重点实验室,天津市代谢性疾病重点实验室,300134

出　　处：《国际内分泌代谢杂志》2022年第6期493-496,共4页International Journal of Endocrinology and Metabolism

摘　　要：糖尿病肾脏病是糖尿病常见且严重的并发症之一,但是目前针对糖尿病肾脏病的治疗仍然有限。补体系统是固有免疫的核心部分,补体系统的过度激活可导致全身性疾病与炎性反应。越来越多的证据表明,补体激活参与了糖尿病肾脏病的发生、发展。本文将介绍补体系统在糖尿病肾脏病中的作用,以及补体靶向治疗作为糖尿病肾脏病治疗靶点的可能性。Diabetes kidney disease is a common and serious complication of diabetes,but the treatment for diabetes kidney disease is still limited.The complement system is the core of innate immunity.The over activation of the complement system can lead to systemic diseases and inflammatory reactions.More and more evidence show that the complement system activation is involved in the occurrence and development of diabetes kidney disease.This article will introduce the role of the complement system in diabetes kidney disease and the possibility of taking the complement system targeted therapy as a therapeutic target for diabetes kidney disease.

关 键 词：糖尿病肾病 补体系统 补体激活酶 膜攻击复合物 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]