眼前段生物测量值与2型糖尿病视网膜病变患者预后的相关性研究  

Study on the correlation between anterior segment biometrics and the prognosis of patients with retinopathy in type 2 diabetes mellitus

作　　者：陈妍鹏[1] 仝真真 李毅[1] Chen Yanpeng;Tong Zhenzhen;Li Yi(Department of Ophthalmology,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院眼科,张家口075000

出　　处：《国际内分泌代谢杂志》2022年第6期516-519,共4页International Journal of Endocrinology and Metabolism

基　　金：2021年度河北省医学科学研究课题计划(20211086)。

摘　　要：目的探讨眼前段生物测量值与糖尿病视网膜病变(DR)患者预后的相关性。方法选取2019年6月至2020年4月就诊于河北北方学院附属第一医院的DR患者120例,随访1年,观察发生视力残疾情况,根据随访结果分为无视力残疾组及视力残疾组。收集两组基础临床资料、实验室检查资料及眼前段生物测量值[角膜中央厚度(CCT)、中央前房深度(ACD)、晶状体厚度(LT)、眼轴长度(AL)],采用logistic多元回归方程分析DR患者发生视力残疾的危险因素。结果随访1年,120例患者中25例发生视力残疾;视力残疾组CCT、LT高于无视力残疾组,ACD、AL低于无视力残疾组(P均<0.05);视力残疾组糖尿病病程长于无视力残疾组,糖化血红蛋白A1c(HbA1c)、空腹血糖、餐后2 h血糖、收缩压、舒张压水平高于无视力残疾组(P均<0.05);糖尿病病程、HbA1c、CCT、LT、收缩压、舒张压为DR患者发生视力残疾的危险因素,ACD、AL为DR患者发生视力残疾的保护因素(P均<0.05)。结论CCT、LT为DR患者发生视力残疾的危险因素,ACD、AL为发生视力残疾的保护因素,早期进行检测有助于评估预后,对制定干预措施具有重要意义。Objective To explore the correlation between the biometric values of the anterior segment of the eye and the prognosis of patients with diabetic retinopathy(DR).Methods A total of 120 cases of DR patients who were treated in the First Affiliated Hospital of Hebei Northern University from June 2019 to April 2020 were selected,followed up for 1 year,and observed the occurrence of visual disability.According to the follow-up results,they were divided into non-visual disability group and the visual disability group.Two groups of basic clinical data,laboratory examination data and biometrics of the front segment Values[central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),axial length(AL)]were collected.The logistic multiple regression equation was used to analyze the risk factors of visual disability in DR patients.Results After 1 year of follow-up,25 out of 120 patients had visual disabilities;The CCT and LT of the visual disability group were higher than those of the non-visual disability group,and ACD and AL were lower than those of the non-visual disability group(all P<0.05).The duration of diabetes in the visual disability group was longer than that in the non-visual disability group,and the levels of glycosylated hemoglobin A1c(HbA1c),fasting blood glucose,2 h postprandial blood glucose,systolic blood pressure and diastolic blood pressure were higher than those in the non-visual disability group(all P<0.05).Duration of diabetes,HbA1c,CCT,LT,systolic blood pressure,and diastolic blood pressure were risk factors for visual disability in DR patients,and ACD and AL were protective factors for visual disability in DR patients(all P<0.05).Conclusions CCT and LT are risk factors for visual disability in DR patients,ACD and AL are protective factors for visual disability.Early detection can help assess the prognosis and is of great significance for the development of intervention measures.

关 键 词：眼前段生物测量值 2型糖尿病 视网膜病变 预后 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]