2018年—2021年北京市大兴区疑似HIV感染样本确证实验结果分析  

Analysis of confirmatory test results of suspected HIV samples in Daxing District, Beijing City from 2018 to 2021

作　　者：周丽敏[1] 王希峰[1] 梁赢[1] 胡月 ZHOU Li-min;WANG Xi-feng;LIANG Ying;HU Yue(Daxing District Center for Disease Control and Prevention,Beijing 102600,China)

机构地区：[1]北京市大兴区疾病预防控制中心,北京102600

出　　处：《中国卫生检验杂志》2022年第23期2862-2864,2869,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的 分析2018年—2021年北京市大兴区疑似艾滋病病毒(HIV)感染样本的确证实验结果,为完善艾滋病检测工作和全区艾滋病防控工作提供依据。方法 参照《全国艾滋病检测技术规范(2015年修订版)(北京修订版)》,采用蛋白免疫印迹法进行确证实验。结果 2018年—2021年大兴区各筛查实验室共送检疑似HIV感染样本1 091份,被判定为HIV抗体阳性705份(64.62%),HIV抗体阴性197份(18.06%),HIV抗体不确定189份(17.32%)。男性HIV抗体阳性率高于女性(P<0.05);不同来源的样本HIV抗体阳性率差异有统计学意义(P<0.01);阳性样本中20岁~59岁人群占比最高,为94.47%。HIV抗体阳性样本中gp160和p66出现频率最高(100.00%)。结论 提高艾滋病检测质量,扩大检测覆盖面,增加MSM、VCT等来源的高危人群的检测率,针对HIV抗体不确定样本,根据检测结果进一步进行核酸检测、流行病学分析等辅助诊断,早确诊、早干预,降低HIV感染性及传播性。Objective This study aims to analyze the confirmatory test results of suspected human immunodeficiency virus(HIV) samples in Daxing District, Beijing City from 2018 to 2021, so as to provide basis for improving the test, prevention and control of acquired immune deficiency syndrome(AIDS) in Daxing District. Methods According to the National Technical Specification for AIDS Testing(Revised in 2015)(Beijing Revised Edition), the confirmation experiment was carried out by Western blot. Results From 2018 to 2021, sentinel laboratories in Daxing District sent 1 091 suspected HIV samples for examination, of which 705 were judged to be HIV antibody positive(64.62%), 197 were HIV antibody negative(18.06%), and 189 were HIV antibody uncertain(17.32%). The positive rate of HIV antibody in men was much higher than that in women(P<0.05). There was statistical significance on the difference in the positive rate of HIV antibody among samples from different sources(P<0.01). The highest proportion of the positive samples was 94.47% among the people aged 20-59. The frequency of gp160 and p66 in HIV antibody positive samples was the highest(100.00%). Conclusion It is necessary to improve the quality of AIDS testing, expand the coverage of testing, increase the testing rate of high-risk groups from MSM, VCT and other sources, further conduct nucleic acid testing, epidemiological analysis and other auxiliary diagnosis based on the testing results for uncertain samples of HIV antibody, as well as conduct early diagnosis and early intervention, so as to reduce the infectivity and transmissibility of HIV.

关 键 词：艾滋病病毒 确证实验 条带 抗体 

分 类 号：R512.91[医药卫生—内科学]