矽肺患者血清中活性维生素D和CC16水平及意义  

The serum levels of active vitamin D and CC16 in patients with silicosis and its clinical significance

作　　者：张红香[1] 张素华[1] ZHANG Hong-xiang;ZHANG Su-hua(Department of Clinical Laboratory,Zibo Occupational Disease Prevention and Treatment Hospital,Shandong 255000,China)

机构地区：[1]淄博市职业病防治院检验科,山东255000

出　　处：《工业卫生与职业病》2023年第1期10-13,共4页Industrial Health and Occupational Diseases

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2020LSD012)。

摘　　要：目的探索矽肺患者血清中活性维生素D[1,25(OH)_(2)D_(3)]、克拉拉细胞分泌蛋白(CC16)含量临床价值。方法以本院89例矽肺患者为矽肺组,以同期无粉尘接触健康检查者60例为对照组,检测2组肺功能指标及血清中1,25(OH)_(2)D_(3)、CC16含量,比较两组血清中1,25(OH)_(2)D_(3)、CC16含量的差异,探讨二者与肺功能的相关性。结果矽肺壹期、贰期、叁期组血清中1,25(OH)2D3含量分别为(16.14±5.35)、(12.44±4.21)、(10.01±3.68)ng/ml均低于对照组(21.92±3.73)ng/m(l t=6.603,10.355,10.784;均P<0.01);矽肺贰、叁期组1,25(OH)_(2)D_(3)含量均低于壹期组(t=3.092,4.008;均P<0.05)。矽肺壹、贰、叁期组血清中CC16水平分别为(12.70±1.90)、(11.04±2.23)、(11.33±1.47)ng/ml均低于对照组(17.92±1.97)ng/ml(t=13.900,14.461,11.750;均P<0.01);贰、叁期矽肺组CC16水平低于壹期组(t=3.410,2.484;均P<0.05)。随着尘龄增加,血清中1,25(OH)2D3、CC16水平均降低,二者呈正相关(r=0.262,P<0.05)。矽肺组血清中1,25(OH)_(2)D_(3)含量与FEV1、FEV1/FVC%均呈正相关(r=0.290、0.230;均P<0.05),血清中CC16含量与FEV1呈正相关(r=0.235,P<0.05)。结论矽肺患者血清中1,25(OH)_(2)D_(3)、CC16含量均降低且与肺功能相关,二者可能具有协同作用,共同参与了矽肺发生、发展,检测二者对矽肺辅助诊断和预后判断有一定参考作用。Objective To investigate the clinical value of serum active vitamin D[1,25(OH)_(2)D_(3)]and Clara cell secreted protein(CC16)in silicosis patients.Methods A total of 89 patients with silicosis in our hospital were selected as the silicosis group.Sixty cases of health examination clients without dust exposure were selected as the control group at the same time.Lung function indicators were examined in the two groups,and the contents of 1,25(OH)_(2)D_(3) and CC16 in serum were detected.The differences of the contents of 1,25(OH)_(2)D_(3) and CC16 in serum of the two groups were compared,and the correlations between the content of 1,25(OH)_(2)D_(3) and CC16 level in serum and lung function indicators were analyzed,respectively.Results The contents of serum 1,25(OH)_(2)D_(3) in the first and second and third stage of silicosis group were(16.14±5.35),(12.44±4.21),(10.01±3.68)ng/ml,respectively,which were lower than those in healthy control group(21.92±3.73)ng/ml(t=6.603,10.355,10.784;all P<0.01).The levels of serum1,25(OH)_(2)D_(3) in the patients with silicosis in the second and third stage groups were lower than those in the first stage group,respectively(t=3.092,4.008;all P<0.05).The contents of serum CC16 in the first and second and third stage of silicosis group were(12.70±1.90),(11.04±2.23),(11.33±1.47)ng/ml,respectively,which were lower than those in healthy control group(17.92±1.97)ng/ml(t=13.900,14.461,11.750;all P<0.01).The levels of serum CC16 in the second and third stage silicosis group were lower than those in the first stage group,respectively(t=3.410,2.484;all P<0.05).With the increase of the exposure time of the dust in silicosis patients,the levels of 1,25(OH)_(2)D_(3) and CC16 in serum decreased,respectively,and the level of 1,25(OH)_(2)D_(3) was positively correlated with CC16 level in serum(r=0.262,P<0.05).In silicosis group,the levels of serum 1,25(OH)_(2)D_(3) were positively correlated with FEV1and FEV1/FVC%,respectively(r=0.290,0.230;all P<0.05),and the level of serum CC16 was positive

关 键 词：1 25(OH)_(2)D_(3) CC16 矽肺 

分 类 号：R135.2[医药卫生—劳动卫生]