改良型自体富血小板纤维蛋白联合重组类人胶原蛋白面膜对女性面部皮肤光老化的修复效果研究  

Study on the repair effect of modified autologous platelet-rich fibrin combined with recombinant human-like collagen mask on female facial skin photoaging

作　　者：陈富禄 唐欷柯 彭智鹏[2] 唐超 粟本义 黎洪棉 韦俊[5] CHEN Fulu;TANG Xike;PENG Zhipeng;TANG Chao;SU Benyi;LI Hongmian;WEI Jun(Department of Surgery,Zhaoping County People′s Hospital,Zhaoping 546800,Guangxi,China;Department of Dermatology,The Fourth People′s Hospital of Nanning,Nanning 530023,Guangxi,China;The Dream Plastic and Cosmetic Hospital of Nanning,Nanning 530021,Guangxi,China;Department of Aesthetic Plastic Surgery,The People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China;Department of Burns and Plastic Surgery,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)

机构地区：[1]昭平县人民医院外科,广西昭平县546800 [2]南宁市第四人民医院皮肤科,广西南宁市530023 [3]南宁梦想整形美容医院,广西南宁市530021 [4]广西壮族自治区人民医院整形美容外科,广西南宁市530021 [5]广西医科大学第一附属医院烧伤整形外科,广西南宁市530021

出　　处：《微创医学》2022年第6期708-713,共6页Journal of Minimally Invasive Medicine

基　　金：广西自然科学基金项目(编号:2021GXNSFAA075018);广西区卫健委自筹经费科研课题(编号:Z20200676、ZA20220149);南宁市良庆区科学研究与技术开发计划项目(编号:202010)。

摘　　要：目的 探讨改良型自体富血小板纤维蛋白(A-PRF)联合重组类人胶原蛋白面膜对女性面部皮肤光老化的修复效果。方法 将80例面部皮肤光老化女性患者通过抽签法分为对照组和治疗组,各40例。对照组单纯使用重组类人胶原蛋白面膜(可丽金)外敷,治疗组在对照组治疗的基础上加用A-PRF治疗,两组均治疗1周。比较治疗前、治疗后1周及1个月,两组患者的皮肤pH值、水分、弹性和油脂分泌情况,以及皮肤色素斑、皱纹、纹理和毛孔情况,观察治疗后1周至1个月的不良反应发生情况。结果 两组患者治疗后1周及1个月,面部皮肤状态均获得不同程度的改善,其中治疗组患者皮肤的皱纹、纹理、毛孔、水分、弹性和油脂方面的改善明显优于对照组,表现为细腻度及光泽度明显增加、细纹减少,主观感受皮肤滋润并有饱满感和弹性等。两组患者在观察期间均无不良反应发生。结论 采用A-PRF联合重组类人胶原蛋白面膜对女性面部光老化皮肤进行修复,可提升面部皮肤的水分和弹性,同时降低油脂、减轻细纹,对女性面部光老化皮肤具有明显的促修复作用,值得临床推广应用。Objective To investigate the repair effect of modified autologous platelet-rich fibrin(A-PRF) combined with recombinant human-like collagen mask on female facial skin photoaging. Methods A total of 80 patients with facial skin photoaging were divided into a control group and a treatment group by drawing lots, with 40 cases in each group. Patients in the control group were treated with recombinant human-like collagen mask(Collgene) for external application, on the basis of which those in the treatment group were additionally treated with A-PRF. Both groups were treated for 1 week. The skin pH value, moisture, elasticity, and grease secretion, as well as skin pigmented spots, wrinkles, texture, and pores were compared between the two groups before treatment, 1 week and 1 month after treatment. And the occurrence of adverse reactions from 1 week to 1 month after treatment was observed. Results The facial skin status improved to various degrees in both groups at 1 week and 1 month after treatment, with the improvement in wrinkles, texture, pores, moisture, elasticity, and grease significantly better in the treatment group than in the control group, as indicated by a significant increase in delicacy and gloss, a decrease in fine wrinkles, and subjective sensation of skin moisturization with fullness and elasticity, etc. No adverse reactions occurred in either group during the observation period. Conclusion Using A-PRF combined with recombinant human-like collagen mask to repair female facial skin photoaging can improve the moisture and elasticity of facial skin, while reducing grease and fine wrinkles. It has an obvious repair effect on female facial skin photoaging and is worthy of clinical promotion and application.

关 键 词：改良型自体富血小板纤维蛋白 重组类人胶原蛋白 光老化 皮肤性质 定量评价 

分 类 号：R758.19[医药卫生—皮肤病学与性病学]