甲状腺抗体三项与早发冠心病相关性研究  

Study on correlation between three thyroid antibodies and early coronary heart disease

作　　者：孙荣亮[1] 沈焱[2] 许瑞庭[3] SUN Rongliang;SHEN Yan;XU Ruiting(Department of Cardiovascular Medicine,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Department of Neurology,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Department of Breast and Nail Surgery,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区人民医院心血管内科,宁夏银川750002 [2]宁夏回族自治区人民医院神经内科,宁夏银川750002 [3]宁夏回族自治区人民医院甲乳外科,宁夏银川750002

出　　处：《宁夏医学杂志》2023年第1期45-47,共3页Ningxia Medical Journal

基　　金：宁夏卫生健康委员会研究课题(2019NW031)。

摘　　要：目的探讨甲状腺抗体三项与早发冠心病的相关性。方法选择接受冠状动脉造影术患者147例为研究对象,根据检查结果分为正常组、单支病变组和多支病变组。所有患者入院后均完成血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、抗甲状腺微粒体抗体(TMAb)、抗甲状腺球蛋白抗体(TGAb)、促甲状腺激素受体抗体(TRAb)水平的测定;采用Pearson相关性分析软件对甲状腺抗体三项与早发冠心病发生率进行相关性分析。结果正常组患者71例,单支病变组患者41例,多支病变组患者35例。3组FT4、TSH水平比较后差异无统计意义(P>0.05);单支病变组和多支病变组FT3水平低于正常组(P<0.05),TMAb、TGAb及TRAb水平高于正常组(P<0.05);多支病变组FT3水平低于单支病变组,TMAb、TGAb及TRAb水平高于单支病变组(P<0.05);Pearson相关性分析结果表明,早发冠心病发生率与FT4、TSH水平无相关性(P>0.05),与FT3水平呈负相关性(P<0.05),与TMAb、TGAb及TRAb水平呈正相关性(P<0.05)。结论甲状腺抗体在冠心病患者中表达异常,其表达水平与早发冠心病发生率存在相关性,加强患者甲状腺抗体水平测定能预测早发冠心病的发生,可指导临床诊疗。Objective To explore the correlation between the three items of thyroid antibody and premature coronary heart disease.Methods 147 patients who underwent coronary angiography were selected as subjects.According to the examination results,they were divided into normal group,single vessel disease group and multivessel disease group.After admission,all patients completed serum free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),anti-thyroid microsomal antibody(TMAb),and anti-thyroglobulin antibody(TGAb),Determination of thyroid stimulating hormone receptor antibody(TRAb)level;Pearson correlation analysis software was used to analyze the correlation between the three thyroid antibodies and the incidence of premature coronary heart disease.Results There were 71 patients in the normal group,41 patients in the single-vessel disease group,and 35 patients in the multi-vessel disease group.After comparison,the levels of FT4 and TSH in the three groups were not statistically significant(P>0.05);the levels of FT3 in the single-vessel disease group and the multivessel disease group were lower than the normal group(P<0.05);the levels of TMAb,TGAb and TRAb were higher than the normal group(P<0.05);The level of FT3 in the multivessel disease group was lower than that of the single vessel disease group;the levels of TMAb,TGAb and TRAb were higher than those in the single vessel disease group(P<0.05);Pearson correlation analysis showed that the incidence of early-onset coronary heart disease and FT4,TSH level has no correlation(P>0.05);it is negatively correlated with FT3 level(P<0.05);it is positively correlated with TMAb,TGAb and TRAb levels(P<0.05).Conclusion Thyroid antibody is abnormally expressed in patients with coronary heart disease,and its expression level is correlated with the incidence of early-onset coronary heart disease.Strengthening the determination of thyroid antibody levels in patients can predict the occurrence of early-onset coronary heart disease and guide clinical diagnosis and tr

关 键 词：甲状腺抗体水平 早发冠心病 冠状动脉造影术 相关性研究 

分 类 号：R541.4[医药卫生—心血管疾病]