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作 者:黄娜[1] 祝伟[1] 贾铷[1] Huang Na;Zhu Wei;Jia Ru(WardⅢ,Department of Paediatrics,Zhengzhou First People’s Hospital,Zhengzhou 450000,China)
机构地区:[1]郑州市第一人民医院儿三病区,郑州450000
出 处:《中国实用医刊》2022年第19期108-111,共4页Chinese Journal of Practical Medicine
摘 要:目的探讨重组人干扰素1b和利巴韦林雾化吸入治疗小儿疱疹性咽峡炎的效果。方法抽取2018年10月至2019年12月郑州市第一人民医院收治的疱疹性咽峡炎患儿82例,按随机数字表法分为A组与B组,每组41例。A组采用重组人干扰素1b雾化吸入治疗,B组采用利巴韦林雾化吸入治疗。对比两组临床疗效、临床症状缓解时间、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、C反应蛋白(CRP)、白细胞介素-10(IL-10)及不良反应发生率。结果A组总有效率(95.12%,39/41)高于B组(80.49%,33/41),P<0.05。A组疱疹消失时间、退热时间、疼痛消失时间及流涎消失时间均短于B组(P<0.05);治疗后,A组IgA、IgG水平高于B组(P<0.05),CRP、IL-10水平低于B组(P<0.05)。A组不良反应发生率(7.32%,3/41)与B组(12.20%,5/41)比较差异未见统计学意义(P>0.05)。结论与利巴韦林雾化吸入治疗比较,重组人干扰素1b治疗小儿疱疹性咽峡炎能提高疗效,可减轻炎症反应、提高免疫功能,促进临床症状改善,并存在用药安全性。Objective To investigate the effect of recombinant human interferon 1b and ribavirin aerosol inhalation in the treatment of herpetic angina in children.Methods Eighty-two children with herpetic angina treated in Zhengzhou First People’s Hospital from October 2018 to December 2019 were selected,and they were divided into group A and group B according to random number table method,with 41 cases in each group.The group A was treated with recombinant human interferon 1b,and the group B was treated with ribavirin aerosol inhalation.The clinical efficacy,clinical symptom relief time,immunoglobulin A(IgA),immunoglobulin G(IgG),C-reactive protein(CRP),interleukin-10(IL-10),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the group A(95.12%,39/41)was higher than that of the group B(80.49%,33/41),P<0.05.The disappearance time of herpes,fever,pain and salivation in the group A were shorter than those in the group B(P<0.05).After treatment,the levels of IgA and IgG in the group A were higher than those in the group B(P<0.05),and the levels of CRP and IL-10 in the group A were lower than those in the group B(P<0.05).There was no significant difference in the incidence of adverse reactions between group A(7.32%,3/41)and group B(12.20%,5/41),P>0.05.Conclusions Compared with ribavirin atomization inhalation therapy,recombinant human interferon 1b in the treatment of children with herpetic angina can improve the curative effect,reduce inflammatory reaction,improve immune function,and promote the improvement of clinical symptoms,with drug safety.
分 类 号:R766.12[医药卫生—耳鼻咽喉科]
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