外泌体治疗支气管肺发育不良的研究进展  

Progress in treatment of bronchopulmonary dysplasia with exosomes

作　　者：潘飞飞 黄栋[1] Pan Feifei;Huang Dong(Pediatric Intensive Care Unit,Affiliated People's Hospital of Guizhou Medical University,Guiyang 550000,China)

机构地区：[1]贵州医科大学附属人民医院儿童重症医学科,贵阳550000

出　　处：《中华围产医学杂志》2022年第12期1010-1014,共5页Chinese Journal of Perinatal Medicine

基　　金：贵州省科技计划项目(黔科合基础-ZK[2021]一般369)。

摘　　要：支气管肺发育不良预后不良。干细胞治疗可能是唯一可促进受损肺修复重建的方法,其机制可能是其产生及分泌的外泌体。外泌体具有抗炎、抗凋亡、抗氧化、抑制肺纤维化及促进受损肺组织再生等功能,有望成为防治支气管肺发育不良的新的切入点。本文就外泌体治疗支气管肺发育不良的研究进展进行综述。Bronchopulmonary dysplasia(BPD)is a poor-prognosis disease.Stem cells may be the only treatment that can promote the repair and reconstruction of damaged lungs through secreting exosomes.Exosomes play crucial roles in anti-inflammatory,anti-apoptosis,anti-oxidation,inhibiting pulmonary fibrosis and promoting regeneration of damaged lung tissues,which are expected to be a new candidate for the prevention and treatment of BPD.This article reviews the research progress in the treatment of BPD with exosomes.

关 键 词：支气管肺发育不良 外泌体 细胞和组织疗法 

分 类 号：R56[医药卫生—呼吸系统]