苯磺酸瑞马唑仑与丙泊酚在老年患者无痛胃肠镜检查中的对比研究  

Comparative study of remazolam besylateand propofol in painless gastroscopy in elderly patients

作　　者：曾琼晶 黄姣艳 刘姝 郭伟华 李佳 ZENG Qiongjing;HUANG Jiaoyan;LIU Shu;GUO Weihua;LI Jia(Department of Anesthesiology,Affiliated Hospital of Jinggangshan University,Ji′an,Jiangxi 343000,China)

机构地区：[1]井冈山大学附属医院麻醉科,江西吉安343000

出　　处：《现代医药卫生》2023年第3期411-414,共4页Journal of Modern Medicine & Health

基　　金：江西省科技厅科技计划项目(2021A19419);江西省吉安市科技局科技计划项目(20210193A)。

摘　　要：目的 比较苯磺酸瑞马唑仑与丙泊酚在老年患者无痛胃肠镜检查中的有效性和安全性。方法 选择2021年1—7月该院80例行无痛胃肠镜检查的老年患者作为研究对象,随机分为观察组与对照组,各40例。2组均静脉注射芬太尼进行镇痛预处理,其中对照组给予丙泊酚注射液,观察组给予苯磺酸瑞马唑仑注射液。比较2组患者操作中生命体征变化,睫毛反射消失时间、苏醒时间及离室时间,术中镇静效果,术后疼痛评分,不良反应的发生率。结果 观察组患者检查中生命体征变化的波动均小于对照组,睫毛反射消失时间、苏醒时间、离室时间明显短于对照组,术中镇静效果、术后疼痛评分优于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论 相较于丙泊酚,苯磺酸瑞马唑仑有效性及安全性更高,不良反应发生率更低。Objective To compare the efficacy and safety of remazolam besylate and propofol in painless gastroscopy in elderly patients.Methods A total of 80 elderly patients undergoing painless gastroscopy from January to July 2021 in this hospital were randomly divided into the observation group and the control group, with 40 cases each.Fentanyl was injected intravenously for analgesia pretreatment in both groups, propofol injection was given to the control group and remazolam besylate injection was given to the observation group.The changes of vital signs, time of eyelash reflex disappearing, time of recovery and leaving room, sedative effect during operation, postoperative pain score and incidence of adverse effects were compared between the two groups.Results The fluctuation of vital signs in the observation group was lower than that in the control group, the time of eyelash reflex disappearing, awakening and leaving hospital in the observation group were significantly lower than those in the control group, the sedation effect and postoperative pain score in the observation group were better than those in the control group, and the incidence of adverse reaction in the observation group was lower than that in the control group, and the differences were statistically significant(P<0.05).Conclusion Compared with propofol, remazolam besylate has higher efficacy and safety, and lower incidence of adverse reactions.

关 键 词：苯磺酸瑞马唑仑 丙泊酚 无痛胃肠镜 对比研究 

分 类 号：R614.2[医药卫生—麻醉学]