中药有效成分防治骨关节炎的作用机制研究进展  

Research progress on mechanism of effective components of traditional Chinese medicine in preventing and treating osteoarthritis

作　　者：李辉 谢兴文 赵永利 李宁[1,2] 李建国 李鼎鹏 陈欣 韩宪富 黄委委 LI Hui;XIE Xing-wen;ZHAO Yong-li;LI Ning;LI Jian-guo;LI Ding-peng;CHEN Xin;HAN Xian-fu;HUANG Wei-wei(Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Northwest University for Nationalities,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]西北民族大学附属医院,甘肃兰州730030

出　　处：《中草药》2022年第23期7543-7552,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81860864);国家自然科学基金资助项目(83160911);国家自然科学基金资助项目(82060873);甘肃省拔尖人才(科学技术领域)培养扶持资金项目(省委人才小组函[2021]2号);甘肃省第二人民医院院内重点项目(YNZD2021-2);中央高校基本科研业务费项目(31920210041)。

摘　　要：骨关节炎是临床上最常见的关节退行性疾病,影响整个关节组织。中药因低不良反应、低成本、多靶点起效等优势在骨关节炎的防治中占据重要位置。研究发现中药有效成分防治骨关节炎的作用机制主要包括减少炎症因子的产生、减轻氧化应激、抑制基质降解酶、调节软骨细胞代谢及调控相关信号通路等方面。主要综述了中药有效成分防治骨关节炎作用机制的研究进展,旨在为进一步研究中药有效成分在骨关节炎防治中的应用价值提供参考和依据。Osteoarthritis is the most common joint degenerative disease in clinic,which affects the whole joint tissue.Traditional Chinese medicine plays an important role in treatment of osteoarthritis because of its advantages such as low adverse reactions,low cost and multi-target effect.It has been found that the mechanisms of effective components of traditional Chinese medicine in prevention and treatment of osteoarthritis mainly include reducing the production of inflammatory factors,reducing oxidative stress,inhibiting matrix degrading enzymes,regulating chondrocyte metabolism and regulating related signaling pathways.The research progress on mechanism of effective components of traditional Chinese medicine in the prevention and treatment of osteoarthritis was reviewed in this paper,to provide reference and basis for further study of the application value of effective components of traditional Chinese medicine in the prevention and treatment of osteoarthritis.

关 键 词：中药有效成分 骨关节炎 炎症因子 氧化应激 基质降解酶 软骨细胞代谢 信号通路 

分 类 号：R282.710.5[医药卫生—中药学]