中药多糖防治阿尔茨海默病作用机制的研究进展  

Research progress on mechanism of traditional Chinese medicine polysaccharides in preventing and treating Alzheimer’s disease

作　　者：张健[1] 李全[1] 周妍妍[1] ZHANG Jian;LI Quan;ZHOU Yan-yan(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中草药》2022年第23期7553-7565,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81774197);国家自然科学基金资助项目(81803984)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的神经退行性疾病,已成为严重威胁老年人身心健康的重要疾病之一,中药因其多靶点、多途径以及性质稳定等特点被广泛应用于治疗AD的实验研究。大量研究表明中药多糖在防治AD中起着重要作用。主要综述了防治AD的中药多糖来源、作用途径,中药多糖防治AD的作用机制(抑制β-淀粉样蛋白生成、降低Tau磷酸化水平、抑制氧化应激、抑制神经炎症、抑制细胞凋亡、调节自噬、改善能量代谢等),旨在为中药多糖类成分防治AD的临床药物开发提供参考和依据。Alzheimer’s disease(AD) is a common neurodegenerative disease,which has become one of the important diseases seriously threatening the physical and mental health of the elderly.Traditional Chinese medicine has been widely used in experimental research on the treatment of AD because of its multi-target,multi-channel and stable nature.A large number of studies have shown that traditional Chinese medicine polysaccharides play an important role in the prevention and treatment of AD.This paper mainly reviewed the source and action way of traditional Chinese medicine polysaccharide for prevention and treatment of AD,and the action mechanism of traditional Chinese medicine polysaccharide for prevention and treatment of AD(inhibition of amyloid β-protein production,reduction of Tau phosphorylation level,inhibition of oxidative stress,inhibition of neuroinflammation,inhibition of cell apoptosis,regulation of autophagy,improvement of energy metabolism,etc.),aiming to provide reference and basis for the clinical drug development of traditional Chinese medicine polysaccharides in the prevention and treatment of AD.

关 键 词：中药多糖 阿尔茨海默病 Β-淀粉样蛋白 TAU磷酸化 氧化应激 神经炎症 细胞凋亡 自噬 能量代谢 

分 类 号：R282.710.5[医药卫生—中药学]