经典名方一贯煎的历史沿革、现代研究进展和质量标志物(Q-Marker)预测分析  

Research progress on historical evolution and modern development of Yiguan Decoction and prediction analysis on its quality marker(Q-Marker)

作　　者：胡钰荧 陈丽[1] 李淑萍 阿吉艾克拜尔·艾萨[1] 吴涛[1] HU Yu-ying;CHEN Li;LI Shu-ping;AISA Haji akber;WU Tao(State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization,Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi 830011,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院新疆理化技术研究所新疆特有药用资源利用重点实验室,新疆乌鲁木齐830011 [2]中国科学院大学,北京100049

出　　处：《中草药》2022年第23期7585-7595,共11页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划项目(2020YFE0205600);中国科学院青年创新促进会优秀会员项目(Y202086);王宽诚教育基金会资助项目。

摘　　要：经典名方一贯煎出自清代魏之琇所著《续名医类案》,为滋阴疏肝之良方。从历史沿革、化学成分和药理作用等方面对一贯煎的研究进展进行综述。根据中药质量标志物(quality marker,Q-Marker)的“五原则”对一贯煎Q-Marker进行预测分析,结果显示花椒毒素、佛手柑内酯、补骨脂素、法卡林二醇、甲基麦冬高异黄酮A、甲基麦冬高异黄酮B、甲基麦冬黄烷酮A、甲基麦冬黄烷酮B、鲁斯可皂苷元、洋川芎内酯I、藁本内酯、阿魏酸、梓醇、地黄苷D、毛蕊花糖苷、甜菜碱和川楝素可作为一贯煎的Q-Marker,为其后续基准样品的制备和新药研发提供参考。Yiguan Decoction(一贯煎),a classical prescription of nourishing yin and soothing liver and treating yin deficiency of liver and kidney,is contained in the Xumingyi Leian written by Wei Zhixiu in the Qing Dynasty.Research progress on historical evolution and chemical constituent and pharmacological effect of Yiguan Decoction were reviewed in this paper.According to “five principles”,the quality markers(Q-Markers) of Yiguan Decoction were predicted in this paper.The results suggested that xanthotoxin,bergapten,psoralen,falcarindiol,methylophiopogonone A,methylophiopogonone B,methylophiopogonanone A,methylophiopogonanone B,ruscogenin,senkyunolide I,ligustilide,ferulic acid,catalpanol,rehmannioside D,calorioside,betaine and azadirachtin could be used as Q-Markers for Yiguan Decoction,which could provide basis and reference for the subsequent preparation of reference samples and further study of preparations.

关 键 词：一贯煎 花椒毒素 佛手柑内酯 补骨脂素 法卡林二醇 甲基麦冬高异黄酮A 甲基麦冬高异黄酮B 甲基麦冬黄烷酮A 甲基麦冬黄烷酮B 鲁斯可皂苷元 洋川芎内酯I 藁本内酯 阿魏酸 梓醇 地黄苷D 毛蕊花糖苷 甜菜碱 川楝素 

分 类 号：R282.710.5[医药卫生—中药学]