枸杞多糖类物质研究现状及发展动态的文献计量学分析  

Bibliometric analysis of research status and development of polysaccharides in Lycii Fructus

作　　者：魏燕 童丽梅 王熙玮 郭盛 钱大玮 段金廒 张芳 WEI Yan;TONG Li-mei;WANG Xi-wei;GUO Sheng;QIAN Da-wei;DUAN Jin-ao;ZHANG Fang(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Ningxia Goqi Innovation Center,Yinchuan 750002,China)

机构地区：[1]南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023 [2]宁夏枸杞创新中心,宁夏银川750002

出　　处：《中草药》2022年第24期7843-7854,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(81773837);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202005);中央本级重大增减支项目(2060302);江苏省高等学校大学生创新创业训练计划项目;宁夏自然科学基金项目(2022AAC03215);宁夏重点研发计划重点项目(2021BEF01003,2021BEF02009)。

摘　　要：目的全面、科学地梳理枸杞多糖研究领域的发展脉络和研究趋势,为相关方向的科学研究、产业发展布局、政府与企业科技资源配置等提供借鉴。方法基于Web of Science数据库对枸杞多糖类物质及其活性表征研究的文献数据进行分析,从枸杞多糖研究的论文整体发表时间分布、研究主体、研究内容及研究热点等方面出发,利用文献计量软件VoSviewer、CiteSpace和R语言环境下的文献计量包Bibliometrix进行分析。结果枸杞多糖研究目前处于快速发展期,我国在研究中处于主体地位,研究机构以国内各高校和科研院所为主,研究机构及团队关联分析提示各研究单元之间的合作交流有待加强;枸杞多糖的研究范围在逐步拓宽,特别是在药理活性与生物学机制研究、提取纯化和结构解析方面取得了良好的进展和积累。结论枸杞多糖与枸杞子药材道地性的内在联系尚不够明确、枸杞多糖医药工业原料生产技术与标准建立亟待加强、枸杞多糖体内代谢过程与构效关系的阐明尚未取得实质性进展,是制约枸杞多糖研究的薄弱环节。Objective To comprehensively and scientifically sort out the development context and research trend of Gouqizi(Lycii Fructus) polysaccharide research and to provide reference for scientific research,industrial development layout,and allocation of scientific and technological resources of governments and enterprises in related fields.Methods Based on the literature data of Lycii Fructus polysaccharides in the Web of Science database,this paper analyzed the literature data of the research on Lycii Fructus polysaccharides and their activity characterization from the perspective of the overall output time distribution,research subjects,research contents and research hotspots.The literature metrology software VOSviewer,CiteSpace and Bibliometrix in R language environment were used for visual analysis.Results The research of Lycii Fructus polysaccharides is currently in a period of rapid development.China played an important role in this research field,and the research institutions were mainly domestic universities and research institutes.The correlation analysis suggested that the cooperation and exchange between various research units need to be strengthened.The research scope of Lycii Fructus polysaccharides is gradually expanding,especially in the study of pharmacological activity and biological mechanism,extraction and purification and structural analysis.Conclusion Weak links restricting the research of Lycii Fructus polysaccharides included:the intrinsic relationship between Lycii Fructus polysaccharides and the authenticity of Lycii Fructus medicinal materials is not clear enough,the establishment of raw material production technology and standards for Lycii Fructus polysaccharides pharmaceutical industry needs to be strengthened urgently,and the elucidation of the metabolic process and structure-activity relationship of Lycii Fructus polysaccharides has not yet made substantial progress.

关 键 词：宁夏枸杞 枸杞子 枸杞多糖 文献计量学 VoSviewer CITESPACE 

分 类 号：R284[医药卫生—中药学] R282[医药卫生—中医学]