乙酰半胱氨酸联合吸入用糖皮质激素对小叶性肺炎患儿肺功能及免疫功能的影响  

Effect of Acetylcysteine Combined with Inhaled Glucocorticoids on Pulmonary Function and Immune Function in Children with Lobular Pneumonia

作　　者：王桂英[1] 田立华[1] WANG Guiying;TIAN Lihua(Siping Maternal and Infant's Hospital,Jilin Province,Siping 136000,China;不详)

机构地区：[1]吉林省四平市妇婴医院,吉林四平136000

出　　处：《中国医学创新》2023年第2期68-72,共5页Medical Innovation of China

摘　　要：目的:探讨乙酰半胱氨酸联合吸入用糖皮质激素对小叶性肺炎患儿肺功能及免疫功能的影响。方法:选取2020年12月-2021年12月四平市妇婴医院收治的200例小叶性肺炎患儿,依据随机数字表法将患儿分成对照组(100例)和观察组(100例)。对照组接受布地奈德雾化吸入治疗,观察组在对照组基础上联合吸入用乙酰半胱氨酸治疗,两组治疗时间均为14 d。比较两组临床疗效、临床症状消失时间、住院时间、用力肺活量(FVC)、最大呼气中段流量(MMEF)、第1秒用力呼气容积(FEV1)、最高呼气流速(PEF)、免疫功能、血清可溶性髓样细胞触发受体-1(s TREM-1)、白细胞介素-4(IL-4)、可溶性血管内皮生长因子受体-1(sFLT-1)水平。结果:治疗后,观察组临床总有效率高于对照组(P<0.05)。观察组咳嗽、高热、气喘、肺啰音消失时间及住院时间均短于对照组,差异均有统计学意义(P<0.05)。与治疗前相比,治疗后两组FVC、PEF、FEV1、MMEF、CD4^(+)、CD8^(+)、血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平均高于治疗前,且观察组均高于对照组;两组血清s TREM-1、IL-4、s FLT-1水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:乙酰半胱氨酸联合吸入用糖皮质激素治疗小叶性肺炎可有效缓解患儿的临床症状,缩短治疗时间,改善患儿肺功能及免疫功能,降低炎症反应,应用效果显著。Objective: To investigate the effect of Acetylcysteine combined with inhaled glucocorticoids on pulmonary function and immune function in children with lobular pneumonia. Method: A total of 200 children with lobular pneumonia treated in Siping Maternal and Infant’s Hospital from December 2020 to December 2021were selected, they were divided into control group(100 cases) and observation group(100 cases) according to the random number table method. The control group received Budesonide atomization inhalation treatment and the observation group received Acetylcysteine on the basis of the control group, the treatment time of both groups were 14 d. The clinical efficacy, disappearance time of clinical symptoms, hospitalization time, forced vital capacity(FVC), maximum mid expiratory flow(MMEF), forced expiratory volume in the first second(FEV1), peak expiratory flow(PEF), immune function, serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1),interleukin-4(IL-4), soluble fms-like tyrosine kinase-1(sFlt-1) levels were compared between the two groups. Result: After treatment, the total effective rate in the observation group was higher than that in the control group(P<0.05). The disappearance time of cough, high fever, asthma, pulmonary rales and hospital stay time in the observation group were shorter than those in the control group, the differences were statistically significant(P<0.05).Compared with before treatment, the levels of FVC, PEF, FEV1, MMEF, CD4^(+), CD8^(+), serum immunoglobulin G(IgG)and immunoglobulin M(IgM) in both groups after treatment were higher than those before treatment, and those in the observation group were higher than those in the control group, serum sTREM-1, IL-4 and sFLT-1 levels in both groups were lower than those before treatment, those in the observation group were lower than those in the control group, the differences were statistically significant(P<0.05). Conclusion: Acetylcysteine combined with inhaled glucocorticoids in the treatment of lobular pneumonia can ef

关 键 词：小叶性肺炎 乙酰半胱氨酸 糖皮质激素 

分 类 号：R725.6[医药卫生—儿科]