CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES  

作　　者：JUNPING ZHONG SIHUA YANG 

机构地区：[1]MOE Key Laboratory of Laser Life Science and Institute of Las er Life Science South China Normal University Guangzhou 510681,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2014年第1期19-25,共7页创新光学健康科学杂志（英文）

基　　金：supported by the National Basic Research Program of China(2011CB910402,2010CB732602);the Program for Changjiang Scholars and Innovative Research Team in University(IRT0829);the National Natural Science Foun-dation of China(81127004,11104087);the Foum-dation for Distinguished Young Talents in Higher Education of Guangdong,China(LYM10061);the Specialized Research Fund for the Doctoral Programof Higher Education(20114407120001);the Sci-ence and Technology Project of Guangzhou,China(2012J4100114).

摘　　要：Contrast agents are attracting a great deal of attention in photoacoustic inaging.Here weintroduce an exogenous contrast agent that provides high photoacoustic signal amplitude at thenear-infrared wavelength._Our_agents consist_of Indocyanine green(ICG)and phospholi-pid-polyethylene glycol(PL-PEG),entitled ICG-PL-PEG nanoparticles,These nanoparticleshave overcome numerous limitations of ICG,such as poor aqueous stability,concentration-dependent aggregation and lack of target specificity.ICG-PL-PEG nanoparticles are bio-compatible and relatively nontoxic.All the components of ICG-PL-PEG nanoparticles havebeen approved for human use.Upon pulsed laser irradiation,the nanoparticles are more eficient inproducing photoacoustic waves than ICG alone.The results showed that ICG-PL-PEG nano-particles act as good contrast agents for photoacoustic imaging.These unique ICG-PL-PEGnanoparticles have great potential in clinical applications.

关 键 词：Photoacoustic imaging NANOPARTICLE indocyanine green phospholipid-polyethyleneglycol. 

分 类 号：TN2[电子电信—物理电子学]