RETINAL SPECTRAL IMAGING AND BLOOD FLOW MEASUREMENT  

作　　者：PAUL LEMAILLET DONALD D.DUNCAN ART LOMPADO MOHAMED IBRAHIM QUAN DONG NGUYEN JESSICA C.RAMELLA-ROMAN 

机构地区：[1]Department of Biomedical Engineering The Catholic University of America 620 Michigan Ave.,N.E.,Washington,DC 20064,USA [2]ECE Department,Portland State University 1900 SW Fourth Avenue,Portland,OR 97201,USA [3]Polaris Sensor Technologies,200 Westside Square Suite 320 Huntsville,AL 35801,USA [4]Wilmer Eye Institute,Johns Hopkins University Baltimore,MD 21287,USA

出　　处：《Journal of Innovative Optical Health Sciences》2010年第4期255-265,共11页创新光学健康科学杂志（英文）

基　　金：the Coulter Foundation and NIH grant#EY017577-01A11.

摘　　要：Measurement of both oxygen saturation and blood flow in the retinal vessels has proved to give important information about the eye health and the onset of eye pathologies such as diabetic retinopathy.In this study,we present the implementation,on a commercially available fundus camera,of a retinal imager and a retina blood flow velocimeter.The retinal imager uses division of aperture to acquire nine wavelength-dependent sub-images of the retina.Careful consideration is taken to improve image transfer by measuring the optical properties of the fundus camera and modeling the optical train in Zemax.This part of the setup is calibrated with optical phantoms of known optical properties that are also used to build a lookup table(LUT)linking phantom optical properties to measured reflectance.The retina blood flow velocimeter relies on tracking clusters of erythrocytes and uses a fast acquisition camera attached to a zoom lens,with a green illumination LED-engine.Calibration is provided using a calibrated quartz capillary tube and human blood at a known flow rate.Optical properties of liquid phantoms are retrieved from measured reflectance using the LUT,and blood flow measurements in the retina are presented.

关 键 词：Retinal oximetry fundus ophthalmoscope multi-aperture camera blood flow velocity diabetic retinopathy 

分 类 号：TB8[一般工业技术—摄影技术]