Visible auto-fluorescence in biological fluids as biomarker of pathological processes and new monitoring tool  

作　　者：A.Kuznetsov A.Frorip A.Maiste M.Ots-Rosenberg A.Sünter 

机构地区：[1]LDiamon AS,Tartu Science Park 181 A.Riia st,51014 Tartu [2]Tartu University,Ulikooli,18,50090 Tartu,Estonia

出　　处：《Journal of Innovative Optical Health Sciences》2015年第3期19-27,共9页创新光学健康科学杂志（英文）

基　　金：support for this work by the Archimedes project 3.2.1101.12-0011.

摘　　要：Comparative optical study of biofluids(serum,urine,hemodialyste)by concentration change ofendogenous visible fluorescence substance(VFS)has been carried out.Biofluids were collectedfrom chronic kidney diseases(CKD)patients(Pts)_as well as from healthy controls(HCs).Exeitation/emission spectra are similar for all samples of biofluids differing only in intensity,which is higher for CKD Pts.Strong similarity enables the study of given biofluids from a unitedphysical platform,proposed earlier,i.e.,as nanoparticles approach.Specific spectral redistribu-tion of visible fluorescence(VF)intensity as a result of dilution is revealed.The concentrationchange of VFS by dilution of samples manifests in nonlinear dependences in the scales"VFintensity-concentration"for serum and urine and in perfect linearity for hemodialysate(HD).The latter fact can be used in monitoring of hemodialysis procedure.

关 键 词：SERUM URINE hemodialysate nanoassociates graphene 

分 类 号：R69[医药卫生—泌尿科学]