Multi-layered tissue head phantoms for noninvasive optical diagnostics  

作　　者：M.S.Wróbel A.P.Popov A.V.Bykov M.Kinnunen M.Jędrzejewska-Szczerska V.V.Tuchin 

机构地区：[1]Department of Metrology and Optoelectronics Gdan
sk University of Technology Gabriela Narutowicza Street 11/1280-233 Gdan
sk,Poland [2]Optoelectronics and Measurement Techniques Laboratory Faculty of Information Technology and Electrical Engineering University of Oulu,P.O.Box 4500 FI-90014 Oulu,Finland [3]Research-Educational Institute of Optics and Biophotonics Saratov State University,Saratov 410012,Russia [4]Institute of Precise Mechanics and Control Russian Academy of Sciences,Saratov 410028,Russia

出　　处：《Journal of Innovative Optical Health Sciences》2015年第3期36-45,共10页创新光学健康科学杂志（英文）

基　　金：the National Science Center,Poland funding allocated on the basis of the decision number DEC-20011/03/D/ST7/03540;Foundation for Polish Science under Grant No.173/UD/SKILLS/2012;DS Programs of the Faculty of Electronics,Telecommunications and Informatics,Gdańsk University of Technology;European Cooperation in Science and Technology (COST)Action BM1205;FiDiPro project 40111/11,TEKES (Finnish Funding Agency for Technology and Innovation);Government of the Russian Federation (Grant No.14.Z50.31.0004 to support scientic research projects implemented under the supervision of leading scientists)and Russian Presidential grant NSh-703.2014.2.

摘　　要：Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human tissues.Development and improvement of in vivo optical measurement systems requires the 1use of stable tissue phantoms with known characteristics,which are mainly used for calibration of such systems and testing their performance over time.Optical and mechanical properties of phantoms depend on their purpose.Nevertheless,they must accurately simulate specific tssues they are supposed to mimic.Many tsues and organs including head possess a multi-layered structure,with specifie optical properties of each layer.However,such a structure is not always addressed in the present-day phantoms.In this paper,we focus on the development of a plain-parallel multi-layered phantom with optical properties(reduced scattering oofficientμ'and absorption cofficientμa)corresponding to the human head layers,such as skin,skul,and gray and white matter of the brain tissue.The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy(NIRS)of humnan brain.Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method.The results show that polyinyl chloride plastisol(PVCP)and zinc oxide(ZnO)nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties.Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

关 键 词：Tissue-mimicking phantoms optical properties near-infrared spectroscopy head model 

分 类 号：TB3[一般工业技术—材料科学与工程]