mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2  

作　　者：Yuxuan Han Yaling An Qian Chen Kun Xu Xueyuan Liu Senyu Xu Huixin Duan Annette B.Vogel Uğur Şahin Qihui Wang Lianpan Dai George F.Gao 

机构地区：[1]Savaid Medical School,University of Chinese Academy of Sciences,Beijing,China [2]Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui,China [3]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China [4]Research Network of Immunity and Health(RNIH),Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing,China [5]Key Laboratory of Tropical Translational Medicine of Ministry of Education,School of Tropical Medicine and Laboratory Medicine,The First Affiliated Hospital,Hainan Medical University,Haikou,Hainan,China [6]School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan,Shandong,China [7]BioNTech SE,Mainz,Germany

出　　处：《Cell Research》2022年第11期1022-1025,共4页细胞研究（英文版）

基　　金：This work is supported by the National Key R&D Program of China(2020YFA0907100),the National Natural Science Foundation of China(NSFC)(82041048 and 81991494)and a grant from the Bill&Melinda Gates Foundation(INV-027420).L.D.is supported by the Excellent Young Scientist Program from NSFC(82122031)and the Chinese Academy of Sciences(YSBR-010).We thank Minrun Duan(Yunnan University),Tianyi Zheng(Zhejiang University),Sheng Liu(Southern University of Science and Technology)and Pei Du(Institute of Microbiology,CAS)for their assistance in the experiments and helpful suggestions.We thank Yuhai Bi,Ning Zhang,and all the staff of ABSL-3 at Institute of Microbiology,CAS for their assistance with the experiments performed in ABSL-3.We are grateful to Tong Zhao in Institute of Microbiology,CAS for her technical assistance with flow cytometry experiments.

摘　　要：Dear Editor,Since emerging in 2019,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused an ongoing human pandemic of coronavirus disease 2019(COVID-19).^(1)Vaccines against COVID-19 were developed and rolled out for large-scale vaccination,including two mRNA vaccines(BNT162b2 and mRNA-1273)encoding SARS-CoV-2 pre-fusion spike protein.

关 键 词：vaccines acute RESPIRATORY 

分 类 号：R563.1[医药卫生—呼吸系统]