Creation of artificial karyotypes in mice reveals robustness of genome organization  

作　　者：Xiaoyu Merlin Zhang Meng Yan Zhenhua Yang Hao Xiang Wei Tang Xindong Cai Qigui Wu Xin Liu Gang Pei Jinsong Li 

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Key Laboratory of Molecular Andrology,Shanghai Institute of Biochemistry and Cell Biology,CAS Center for Excellence in Molecular Cell Science,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,China [2]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang,China [3]School of Life Science and Technology,ShanghaiTech University,Shanghai,China [4]State Key Laboratory of Molecular Biology,Shanghai Institute of Biochemistry and Cell Biology,CAS Center for Excellence in Molecular Cell Science,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,China

出　　处：《Cell Research》2022年第11期1026-1029,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program of China and the National Natural Science Foundation of China(2019YFA0109900,2020YFA0509000,31821004,32030029,31730062);partly supported by China Postdoctoral Science Foundation(2021TQ0329).

摘　　要：Dear Editor,Robertsonian(Rb)fusions contribute to the diversity in species karyotypes.However,how it occurs and propels evolution is still unknown,mainly due to the lack of a simple and efficient method for genetically manipulating chromosomes in animals.While the typical mousekaryotype(2n=40)iscompletelytelocentric exceptchromosomeY(ChrY),thewestern European subspeciesM.m.domesticus contains diverse chromosomal races,with a diploid number varying between 38 and 22 due to carrying one or multiple pairs of metacentric chromosomes,which results from the Rb fusions between two telocentricchromosomes.

关 键 词：artificial KARYOTYPE 

分 类 号：Q95[生物学—动物学]