piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells  

作　　者：Mao-Zhou Zhao Di-Hang Lin Heng Zuo Huan Wei Xin Wang Lan-Tao Gou Mo-Fang Liu 

机构地区：[1]State Key Laboratory of Molecular Biology,State Key Laboratory of Cell Biology,Shanghai Key Laboratory of Molecular Andrology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences [2]University of Chinese Academy of Sciences,Shanghai,China [3]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang,China

出　　处：《Cell Research》2022年第11期1030-1033,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program of China(2017YFA0504400,2021YFC2700200);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19010203);the National Natural Science Foundation of China(91940305,31830109,31821004,31961133022,91640201,32170815,32101037);Science and Technology Commission of Shanghai Municipality(17JC1420100,2017SHZDZX01,19JC1410200,21PJ1413800,21ZR1470200,21YF1452700,21ZR1470500);China Postdoctoral Science Foundation(2020T130670,2020M671256);the Foundation of Key Laboratory of Gene Engineering of the Ministry of Education.

摘　　要：Dear Editor,RNA tailing,i.e.,addition of non-templated nucleotides to the 3'endof RNAs,representsoneofthemostfrequent RNA modifications that participate in regulation of RNA processing,function,degradation,etc.^(1)PIWI-interacting RNAs(piRNAs)are a class of animal germline-specific small non-coding RNAs that guide PIWI proteins to suppress transposable elements and regulateprotein-codinggenes ingermcelis,playing indispensable roles ingermlinedevelopmentandfertility in animals.

关 键 词：TEMPLATE FERTILITY indispensable 

分 类 号：Q2[生物学—细胞生物学]