益生菌调节肠道黏膜免疫研究进展  

Research progress in probiotic bacteria modulating intestinal mucosal immunity

作　　者：王涛[1] 田欣蕾 张迪[1] 李娜 钱爱东[1] 单晓枫[1] 王春凤[1] 张冬星[1] WANG Tao;TIAN Xinlei;ZHANG Di;LI Na;QIAN Aidong;SHAN Xiaofeng;WANG Chunfeng;ZHANG Dongxing(College of Animal Science and Technology/College of Veterinary Medicine,Jilin Agricultural University,Changchun 130118,China;Bureau of Agriculture and Rural Affairs of Mudanjiang,Mudanjiang,Heilongjiang 157020,China)

机构地区：[1]吉林农业大学动物科学技术学院/动物医学学院,吉林长春130118 [2]牡丹江市农业农村局,黑龙江牡丹江157020

出　　处：《中国兽医学报》2022年第12期2578-2584,共7页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金青年科学基金资助项目(32102681)。

摘　　要：肠是脊椎动物最大的免疫器官,肠黏膜免疫稳态需具备良好的黏膜上皮屏障完整性,提高吸收能力从而抵御病原的侵袭。因此,肠上皮屏障功能的破坏会导致多种肠道疾病。肠上皮屏障包括多种肠上皮细胞,其除消化作用外还可调节肠黏膜免疫反应。肠道内存在大量共生菌群,这些微生物对营养物质的摄入、新陈代谢和免疫稳态具有调节作用,其中益生菌可调节肠道屏障功能并激活黏膜免疫应答。阐述黏膜相关免疫细胞的功能,介绍益生菌及工程菌的免疫调节特性,基于黏膜免疫及其机制的研究来分析并比较不同益生菌对黏膜免疫的调节作用,以期为预防疾病、缓解肠道损伤及黏膜疫苗的研制奠定理论基础。The intestine is the largest immune-related organ in vertebrate.The maintenance of intestinal mucosal homeostasis is dependent on good mucosal epithelial barrier integrity,which can improve absorption capacity and prevent pathogen invasion.Disruption of epithelial barrier integrity can lead to a variety of intestinal diseases.The intestinal epithelial barrier consists of various intestinal epithelial cells.In addition to digestion,the intestinal epithelial cells also can regulate the intestinal mucosal immune responses.A large number of commensal flora colonize in the intestine.The microbiota can regulate the uptake of nutrient components,cell metabolism,and immune homeostasis.Notably,the probiotics contribute to improving mucosal barrier function and triggering mucosal immunity.Here,we described the functions of mucosa-associated immune cells and introduced the immunomodulatory properties of probiotics and engineered probiotics.Based on the study of mucosal immunity and mechanism,we analyzed the effects of different probiotics on mucosal immunity,which will provide the theoretical foundation for the prevention and alleviation of intestinal diseases and the development of the mucosal vaccine.

关 键 词：肠道屏障 黏膜免疫细胞 益生菌 共生菌群 

分 类 号：S852.4[农业科学—基础兽医学] S852.61[农业科学—兽医学]