替比夫定治疗HBsAg阳性孕妇的母婴阻断效果及其影响因素分析  

Analysis of the Mother-infant Blocking Effect and Its Influencing Factors of Telbivudine in the Treatment of HBsAg Positive Pregnant Women

作　　者：彭福江[1] 张天晓[1] 袁美蓉[1] PENG Fujiang;ZHANG Tianxiao;YUAN Meirong(Dongguan Chang'an Hospital,Guangdong Province,Dongguan 523843,China;不详)

机构地区：[1]广东省东莞市长安医院,广东东莞523843

出　　处：《中国医学创新》2023年第4期172-175,共4页Medical Innovation of China

摘　　要：目的:探讨替比夫定(LdT)治疗乙型肝炎表面抗原(HBsAg)阳性孕妇的母婴阻断效果及其影响因素。方法:选取东莞市长安医院2018年1月-2021年10月收治的HBsAg阳性孕妇81例,均采用LdT治疗,收集患者一般资料,分析LdT治疗HBsAg阳性孕妇的母婴阻断效果及其影响因素。结果:81例婴儿中,HBsAg阳性率为4.94%(4/81),HBsAg阴性率为95.06%(77/81)。母婴阻断失败组与母婴阻断成功组孕妇HBV-DNA高载量、用药时间短、前置胎盘、早产、胎盘早剥比较,差异均有统计学意义(P<0.05);两组年龄、分娩史、吸烟、饮酒、涂抹指甲油、规律产检比较,差异均无统计学意义(P>0.05)。logistic回归分析显示,孕妇HBV-DNA高载量、用药时间短、前置胎盘、早产、胎盘早剥均是HBsAg阳性孕妇母婴阻断成功的危险因素(P<0.05)。结论:LdT治疗HBsAg阳性孕妇的母婴阻断成功率较高,HBV-DNA高载量、用药时间短、前置胎盘、早产、胎盘早剥与HBsA g阳性孕妇母婴阻断失败有关。Objective:To investigate the mother-infant blocking effect and its influencing factors of Telbivudine(LdT)in the treatment of hepatitis B surface antigen(HBsAg)positive pregnant women.Method:A total of 81 HBsAg positive pregnant women who were admitted to Dongguan Chang'an Hospital from January 2018 to October 2021 were selected and treated with LdT.The general data of the patients were collected and the mother-infant blocking effect of LdT in the treatment of HBsAg positive pregnant women and its influencing factors were analyzed.Result:In 81 infants,the positive rate of HBsAg was 4.94%(4/81),and the negative rate of HBsAg was 95.06%(77/81).The high HBV-DNA load in pregnant women,short medication time,placenta previa,premature delivery and placental abruption between the mother-infant blocking failed group and the mother-infant blocking successful group,the differences were statistically significant(P<0.05).There were no significant differences between the two groups in age,delivery history,smoking,drinking,applying nail polish before or during pregnancy and regular check-up(P>0.05).logistic regression analysis showed that high HBV-DNA load in pregnant women,short medication time,placenta previa,premature delivery and placenta abruption were all risk factors of mother-infant blocking succeeded in HBsAg positive pregnant women(P<0.05).Conclusion:LdT treatment in HBsAg positive pregnant women has a high success rate of mother-infant blocking.High HBV-DNA load,short medication time,placenta previa,premature delivery and placenta abruption are related to the failure of mother-infant blocking in HBsAg positive pregnant women.

关 键 词：替比夫定 乙型肝炎表面抗原 母婴阻断 用药时间 

分 类 号：R512.62[医药卫生—内科学]