生物活性多肽在肝脏缺血再灌注损伤中的研究进展  

Advances of bioactive peptides in hepatic ischemia/reperfusion injury

作　　者：鲍群 韩波[2] 孙鹏[1] Bao Qun;Han Bo;Sun Peng(Department of General Surgery,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200050,China;Key Laboratory for Translational Research and Innovative Therapeutics of Gastrointestinal Oncology,Hongqiao International Institute of Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)

机构地区：[1]上海交通大学医学院附属同仁医院普外科,上海200050 [2]上海交通大学医学院虹桥国际医学研究院、胃肠道肿瘤转化研究与创新治疗重点实验室,上海200336

出　　处：《国际外科学杂志》2022年第12期842-848,共7页International Journal of Surgery

基　　金：国家自然科学基金(82070634);上海市医学重点专科(ZK2019A15)。

摘　　要：肝脏缺血再灌注损伤(HIRI)是肝脏经过肝切除、肝移植等外科干预或全身出血性休克后所出现的损伤,能够导致严重的术后并发症,已强烈威胁到边缘性供肝的利用和患者的临床转归。因此,如何有效干预HIRI一直是肝脏外科领域的重要话题。虽然HIRI的病理生理机制正逐渐被阐明,但目前临床上仍未出现对抗该损伤的防治措施。生物活性多肽是不具有蛋白质四级结构的小分子物质,能够在体内高效调节如应激、代谢等生理进程,同时参与疾病的发生与发展。近年来随着胰岛素等肽类制剂在临床中的成功应用,生物活性多肽在HIRI领域中的作用也得到了广泛关注。目前已有多项研究报道生物活性多肽能够对抗HIRI,展现出巨大的肝脏保护潜能。因此,本文针对近年来生物活性多肽在HIRI中的研究作一综述,以期为干预HIRI提供新视角。Hepatic ischemia/reperfusion injury(HIRI)occurs in liver surgical interventions or systemic hemorrhagic shock,especially in liver transplantation,which can lead to serious postoperative complications and strongly threats the utilization of marginal donor livers and the prognosis of recipients.Here,how to effectively intervene HIRI has always been the important topic in liver surgery.The pathogenesis of HIRI has been gradually elucidated,but no effective prevention and treatment measures have been performed to reduce the injury in clinic.Peptides are small molecules without a quaternary protein structure,which can effectively regulate physiological processes such as stress and metabolism in the body,and participate in the occurrence and development of diseases.Recently,with the successful application of insulin and other peptides in the bedside,the effect of bioactive peptides on HIRI has been attracting wide attention,numbers of studies have confirmed that bioactive peptides have great potential for liver protection during HIRI.This article reviews the roles of bioactive peptides in HIRI and provides new sight and reference to protect liver from HIRI.

关 键 词：肝 再灌注损伤 胰多肽 肝移植 肝脏缺血再灌注损伤 

分 类 号：R657.3[医药卫生—外科学]