精子DNA碎片检测的临床专家共识  

Clinical expert consensus on sperm DNA fragmentation detection

作　　者：倪吴花 Ashok Agarwal[1] 孙莹璞 孙海翔[1] 邓成艳[1] 刘平 周灿权[1] 冯云[1] 郝桂敏[1] 卢文红 全松[1] 沈浣[1] 师娟子[1] 滕晓明[1] 王晓红 王秀霞 伍琼芳[1] 曾勇[1] 张松英 钟影[1] 黄学锋 黄国宁[1] NI Wu-hua;Ashok Agarwal;SUN Ying-pu;SUN Hai-xiang;DENG Cheng-yan;LIU Ping;ZHOU Can-quan;FENG Yun;HAO Gui-min;LU Wen-hong;QUAN Song;SHEN Huan;SHI Juan-zi;TENG Xiao-ming;WANG Xiao-hong;WANG Xiu-xia;WU Qiong-fang;ZENG Yong;ZHANG Song-ying;ZHONG Ying;HUANG Xue-feng;HUANG Guo-ning(The Fifth Committee of Chinese Society of Reproductive Medicine,Chinese Medical Association)

机构地区：[1]中华医学会生殖医学分会第五届委员会 [2]温州医科大学附属第一医院生殖医学中心

出　　处：《生殖医学杂志》2023年第2期170-180,共11页Journal of Reproductive Medicine

摘　　要：精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助生殖技术结局存在负相关,SDF检测已在男性不育症和辅助生殖技术中得到越来越广泛的应用。本专家共识复习和评估了SDF相关文献,对SDF的危险因素、检测方法、临床意义和处理等提出2项良好实践要点和9项推荐建议。本共识大部分推荐建议的证据和级别属于低或中等,表明仍需要进一步的研究证实临床应用SDF检测的价值。The incidence of sperm DNA fragmentation(SDF)is higher in male infertile patient.SDF is often associated with oligozoospermia and asthenospermia,and can also occur in infertile patients with normal conventional semen parameters.The mechanisms include abnormal spermatozoa maturation process,abnormal apoptosis,and high oxidative stress.SDF detection has been widely used in male infertility and assisted reproductive technology(ART)due to the negative correlation between SDF and the outcome of natural pregnancy and ART reported in many literatures.This expert consensus reviewed and evaluated SDF related literature,and proposed 2 good practice points and 9 recommendations on risk factors,detection methods,clinical significance and treatment of SDF.The evidence and level of the most recommendations in this consensus are low or medium,indicating that further research is still needed to confirm the value of clinical application of SDF detection.

关 键 词：男性不育 精子DNA碎片 辅助生殖技术 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学] R698.2[医药卫生—基础医学]