改良IVF正常受精率计算公式在获卵少周期中的应用及资料分析  

Application of modified formula of IVF normal fertilization rate in cycles with fewer oocytes retrieved and data analysis

作　　者：蒋彦[1] 袁景川[1] 耿彩平[1] 宋歌[1] 张旭慧 曹尧南 JIANG Yan;YUAN Jing-chuan;GENG Cai-ping;SONG Ge;ZHANG Xu-hui;CAO Yao-nan(The Fourth Hospital of Shijiazhuang,Shijiazhuang Obstetrics and Gynecology Hospital of Hebei Medical University,Shijiazhuang 050011)

机构地区：[1]石家庄市第四医院河北医科大学石家庄市妇产医院生殖医学中心,石家庄050011

出　　处：《生殖医学杂志》2023年第2期208-213,共6页Journal of Reproductive Medicine

基　　金：河北省卫生健康委科技成果推广课题(20231650)。

摘　　要：目的 探讨改良IVF正常受精率计算公式在获卵数少周期中的应用。方法 回顾性分析2015年1月至2022年5月于我院生殖医学中心行IVF/ICSI助孕治疗、获卵少(获卵1~3枚)患者的临床资料,共1 777个周期。根据授精方式不同分为IVF组(行IVF授精,1 192个周期)和ICSI组(行ICSI授精,585个周期),比较两组患者的一般资料、MⅡ卵率、正常受精率、改良正常受精率、优质胚胎率和可用胚胎率等。结果 2015年1月至2022年5月在我中心行辅助生殖治疗的患者中获卵少的周期共1 777个周期,占所有取到卵周期的比例为15.8%(1 777/11 231)。IVF组和ICSI组患者的一般资料比较无显著性差异(P>0.05)。IVF组的MⅡ卵率(89.9%vs. 81.4%)、优质胚胎率(51.0%vs. 43.1%)和可用胚胎率(84.6%vs. 74.8%)均显著高于ICSI组(P<0.05),正常受精率显著低于ICSI组(75.1%vs. 86.3%,P<0.05);而采用改良公式计算后,IVF组的改良正常受精率为83.6%,与ICSI组(86.3%)比较无显著性差异(P>0.05)。结论 对获卵少、非男性因素不孕的患者,采用改良IVF正常受精率的计算公式能更好地反映成熟卵受精情况。Objective:To explore the application of modified formula of IVF normal fertilization rate in the cycles with fewer oocytes retrieved.Methods:The clinical data of the patients who received IVF/ICSI assisted pregnancy treatment and had fewer oocytes retrieved(1-3 oocytes) in the Reproductive Medical Center of our hospital from January 2015 to May 2022 were analyzed retrospectively(n=1 777 cycles). The patients were divided into IVF group(1 192 cycles of IVF insemination) and ICSI group(585 cycles of ICSI insemination) according to different insemination methods. The general data, MⅡ oocyte rate, normal fertilization rate, modified normal fertilization rate, high-quality embryo rate and available embryo rate were compared between the two groups.Results:There were 1 777 cycles with low oocytes retrieved among the patients received assisted reproductive treatment in our center from January 2015 to May 2022,accounting for 15.8% of all cycles of oocyte retrieval(1 777/11 231). There was no significant difference in general data between IVF group and ICSI group(P>0.05). The MⅡoocyte rate(89.9% vs. 81.4%),high-quality embryo rate(51.0% vs. 43.1%) and available embryo rate(84.6% vs. 74.8%) in IVF group were significantly higher than those in ICSI group(P<0.05),and the normal fertilization rate was significantly lower than that in ICSI group(75.1% vs. 86.3%,P<0.05). The modified normal fertilization rate in IVF group was 83.6%,which was not significantly different with ICSI group(86.3%)(P>0.05).Conclusions:The modified formula of IVF normal fertilization rate can better reflect the status of fertilization of mature oocytes in patients with fewer oocytes retrieved and infertility due to non-male factors.

关 键 词：体外受精 受精率 MⅡ卵率 获卵数少 

分 类 号：R711.6[医药卫生—妇产科学]