Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul  

作　　者：Berkin Berk Akbeyaz AyŞe Karaaslan CerenÇetin Mehmet Tolga Köle Zeynep AltaŞ Yasemin Akın 

机构地区：[1]Department of Pediatrics,University of Health Sciences,Kartal Dr.Lütfi Kirdar City Hospital,Pediatric Hematology and Oncology Istanbul,Turkey [2]Department of Pediatric Infectious Diseases,University of Health Sciences,Kartal Dr.Lütfi Kirdar City Hospital,Istanbul,Turkey [3]Department of Pediatrics,University of Health Sciences,Kartal Dr.Lütfi Kirdar City Hospital,Istanbul,Turkey [4]Department of Public Health,Marmara University,Istanbul,Turkey

出　　处：《Asian Pacific Journal of Tropical Medicine》2022年第12期551-557,共7页亚太热带医药杂志（英文版）

摘　　要：Objective:To examine the effect of the COVID-19 virus,especially the Omicron variant,on hematological parameters of hospitalized pediatric patients during the COVID-19 pandemic.Methods:Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr.Lütfi K?rdar City Hospital in Istanbul,Turkey,between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics,SARS-Co V-2 infection polymerase chain reaction(PCR)test results,reversetranscriptase(RT)-PCR for other respiratory agents,duration of hospital stay,and hematological and biochemical laboratory findings.Results:Out of 467 children with a confirmed diagnosis of SARSCo V-2 infection,94(20.1%)had Omicron infection and 373(79.9%)were infected with other variants;the Omicron group had younger patients than the remaining samples(P<0.001).The most frequent clinical symptoms in all children were cough(53.5%)and fever(32.3%),followed by vomiting(20.8%).Lung involvement in the Omicron group(10.6%)was significantly lower than in the remaining samples(29.8%)(P<0.001).Hemoglobin and lymphocyte levels were lower in the Omicron-infected group(both P<0.001),while prothrombin time,activated partial thromboplastin time,international normalized ratio,and D-dimer levels were significantly higher in this group(P<0.001,P<0.001,P<0.001,and P=0.023,respectively).In terms of lung involvement,those with lung involvement were significantly older(P<0.001).Conclusions:Although lung involvement was less common with Omicron infection,this group had greater hematological system involvement,such as anemia,lymphopenia,D-dimer elevation,and coagulation disorders.

关 键 词：COVID CHILDREN Omicron Hematologic findings 

分 类 号：R725.1[医药卫生—儿科]