三种常见革兰阴性菌的毒力与耐药性关系的研究进展  

Relationship between Virulence and Antimicrobial Resistance in Three Common Gram-Negative Bacteria Species

作　　者：杜瑾鸿 张泽宇 刘祎佳 范馨月 刘怡蕾 刘理慧 程古月 Du Jin-hong;Zhang Ze-yu;Liu Yi-jia;Fan Xin-yue;Liu Yi-lei;Liu Li-hui;Cheng Gu-yue(College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070;Tianjin Ringpu Bio-technology Co.Ltd.,Tianjin 300000;National Veterinary Antimicrobial Residue Reference Laboratory,Huazhong Agricultural University,Wuhan 430070)

机构地区：[1]华中农业大学动物科学技术学院-动物医学院,武汉430070 [2]天津瑞普生物技术股份有限公司,天津300000 [3]华中农业大学国家兽药残留基准实验室,武汉430070

出　　处：《国外医药（抗生素分册）》2022年第5期297-305,共9页World Notes on Antibiotics

基　　金：国家自然科学基金(No.32072921);湖北省大学生创新创业训练计划项目(No.S202110504037);华中农业大学大学生科技创新基金(SRF)项目(No.2021032)。

摘　　要：在革兰阴性菌中,耐药性与毒力并非两个互不相干的性状,相反,两者间有着非常紧密的联系。在耐药性问题日渐紧迫的背景下,耐药性与毒力之间的关系可能为控制耐药菌策略带来一定的启示。尽管有关耐药—毒力关系的研究成果日积月累,对这方面及时的系统的总结却膛乎其后。细菌的耐药—毒力关系在不同细菌中有所不同,亦受耐药性和毒力的具体机制及宿主等多方面因素的影响。本文现对三种常见的革兰阴性菌[铜绿假单胞菌(Pseudomonas aeruginosa)、大肠埃希菌(Escherichia coli)和沙门菌(Salmonella)]的耐药—毒力关系及其已发现的机制进行综述,以期为耐药—毒力关系的全面认识提供一种新的视角。Rather than separate from each other,the antimicrobial resistance and the virulence of Gram-negative bacteria are highly related,which could bring some implications for the containment of antimicrobial-resistant bacteria providing the raising problem of antimicrobial resistance.Despite the mounting revelations about resistance-virulence relationship,systematic reviews are still being few.The resistance-virulence relationship depends mainly on species of bacteria,the specific mechanism of resistance and virulence and the host etc.Here,this relationship and its found mechanism among three common Gram-negative bacteria species(Pseudomonas aeruginosa,Escherichia coli and Salmonella)is reviewed,such that a novel perspective can be provided for the comprehensive understanding of resistance-virulence relationship.

关 键 词：抗菌药 耐药性 毒力 革兰阴性菌 相关性 

分 类 号：R978.1[医药卫生—药品]