中药单体干预前列腺癌的作用机制研究进展  

Progress of Research on the Mechanism of Action of Traditional Chinese Medicine Monomers in Prostate Cancer Intervention

作　　者：王华婷 俞采妮 康媛源 李丹[1] WANG Huating;YU Caini;KANG Yuanyuan;LI Dan(College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学药学院,浙江杭州310058

出　　处：《药学进展》2022年第12期951-960,共10页Progress in Pharmaceutical Sciences

基　　金：浙江大学本科生科研实践计划项目(No.P2021072);科技部重点研发计划项目(No.2019YFE0111300)。

摘　　要：前列腺癌是全球男性常见的恶性肿瘤,在我国也有较高的发病率和死亡率。中药单体结构明确且来源丰富,在开发前列腺癌治疗药物方面有着独特的优势。围绕雄激素受体依赖和雄激素受体非依赖两个方面综述了中药单体在前列腺癌治疗中的作用机制,以期为探索中药治疗前列腺癌的具体方案提供参考,为新型前列腺癌治疗药物的开发提供有用信息。Prostate cancer(PCa),a common malignancy in men worldwide,has a high rate of morbidity and mortality in China.With their confirmed structures and rich sources,traditional Chinese medicine(TCM)monomers have their special advantages for developing anti-PCa drugs.This study reviews the action mechanisms of TCM monomers in the treatment of PCa from androgen receptor(AR)dependence and AR independence,so as to provide some reference for the exploration of specific PCa therapeutic regimens using TCM and useful information for the development of novel drugs treating PCa.

关 键 词：前列腺癌 雄激素受体 作用机制 中药单体 

分 类 号：R979.1[医药卫生—药品] R966[医药卫生—药学]